Search
Proteintech
Annexin A2 Monoclonal Antibody (1C1E12)
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Product Details
66035-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
1C1E12
Immunogen
Annexin A2 Fusion Protein Ag16654 (1-339 aa encoded by BC016774)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
150 µg
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MSTVHEILC KLSLEGDHST PPSAYGSVKA YTNFDAERDA LNIETAIKTK GVDEVTIVNI LTNRSNAQRQ DIAFAYQRRT KKELASALKS ALSGHLETVI LGLLKTPAQY DASELKASMK GLGTDEDSLI EIICSRTNQE LQEINRVYKE MYKTDLEKDI ISDTSGDFRK LMVALAKGRR AEDGSVIDYE LIDQDARDLY DAGVKRKGTD VPKWISIMTE RSVPHLQKVF DRYKSYSPYD MLESIRKEVK GDLENAFLNL VQCIQNKPLY FADRLYDSMK GKGTRDKVLI RIMVSRSEVD MLKIRSEFKR KYGKSLYYYI QQDTKGDYQK ALLYLCGGDD (1-339 aa encoded by BC016774)
Target Information
This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions as an autocrine factor which heightens osteoclast formation and bone resorption. This gene has three pseudogenes located on chromosomes 4, 9 and 10, respectively. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 33-kDa calcimedin; 33-kDa lymphocyte Ca<2+>- binding protein; 33kDa lymphocyte Ca<2+>- binding protein; 36-kDa calelectrin; Annexin A2; Annexin II; Annexin-2; Calpactin I heavy chain; calpactin I heavy polypeptide; Calpactin-1 heavy chain; chromobindin 8; Chromobindin-8; epididymis secretory protein Li 270; epididymis secretory sperm binding protein; Lipocortin II; p36; PAP-IV; Placental anticoagulant protein IV; Protein I; unnamed protein product
Gene Aliases: ANX2; ANX2L4; ANXA2; AW215814; CAL1H; HEL-S-270; LIP2; LPC2; LPC2D; P36; PAP-IV
UniProt ID: (Human) P07355, (Mouse) P07356, (Rat) Q07936
Entrez Gene ID: (Human) 302, (Mouse) 12306, (Rat) 56611
phosphatidylserine binding
protease binding
RNA binding
phospholipase inhibitor activity
serine-type endopeptidase inhibitor activity
calcium ion binding
protein binding
calcium-dependent phospholipid binding
phosphatidylinositol-4,5-bisphosphate binding
cytoskeletal protein binding
phospholipase A2 inhibitor activity
identical protein binding
S100 protein binding
calcium-dependent protein binding
cadherin binding involved in cell-cell adhesion
Rab GTPase binding
receptor activator activity
poly(A) RNA binding
actin filament binding
calcium-binding protein
angiogenesis
membrane raft assembly
positive regulation of receptor recycling
negative regulation of receptor internalization
membrane budding
cell adhesion
cell-matrix adhesion
positive regulation of plasminogen activation
response to activity
collagen fibril organization
lung development
positive regulation of vesicle fusion
negative regulation of low-density lipoprotein particle receptor catabolic process
osteoclast development
fibrinolysis
mRNA transcription from RNA polymerase II promoter
positive regulation of vacuole organization
positive regulation of exocytosis
positive regulation of transcription from RNA polymerase II promoter
regulation of neurogenesis
negative regulation of transport
positive regulation of multicellular organismal process
cell-cell adhesion
epithelial cell apoptotic process
positive regulation of low-density lipoprotein particle clearance
positive regulation of receptor-mediated endocytosis involved in cholesterol transport
positive regulation of plasma membrane repair
positive regulation of protein phosphorylation
body fluid secretion
negative regulation of catalytic activity
positive regulation of fibroblast proliferation
positive regulation of binding
protein heterotetramerization
cellular response to acid chemical
protein targeting to plasma membrane
negative regulation of receptor binding
positive regulation of receptor activity
regulation of fibrinolysis
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support