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Cyclophilin B Monoclonal Antibody (8H4F1)
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Product Details
66047-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
8H4F1
Immunogen
Cyclophilin B Fusion Protein Ag17957 (1-216 aa encoded by BC032138)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MLRLSERNM KVLLAAALIA GSVFFLLLPG PSAADEKKKG PKVTVKVYFD LRIGDEDVGR VIFGLFGKTV PKTVDNFVAL ATGEKGFGYK NSKFHRVIKD FMIQGGDFTR GDGTGGKSIY GERFPDENFK LKHYGPGWVS MANAGKDTNG SQFFITTVKT AWLDGKHVVF GKVLEGMEVV RKVESTKTDS RDKPLKDVII ADCGKIEVEK PFAIAKE (1-216 aa encoded by BC032138)
Target Information
Immunophilins are a family of soluble cytosolic receptors capable of binding to one of two major immunosuppressant agents - cyclosporin A (CsA) or FK506. Proteins which bind FK506 are termed FK506 Binding Proteins (FKBP's) and those which bind cyclosporin A are called cyclophilins (CyP). Both CyP:CsA and FKBP:FK506 complexes have been shown to inhibit calcineurin, a calcium and calmodulin dependent protein phosphatase which has been implicated as an important signaling enzyme in T-cell activation. Thus, providing a possible mechanism of immunosuppression by CsA and FK506. Immunophilins function as peptidyl prolyl cis-trans-isomerases (PPIase) whose activity is inhibited by their respective immunosuppressant compounds. As PPIase's, immunophilins accelerate folding of some proteins both in vivo and in vitro by catalyzing slow steps in the initial folding and rearrangement of proline containing proteins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cyclophilin B; cyclophilin-like protein; Cyp B; CYP-S1; EC 5.2.1.8; epididymis secretory protein Li 39; Peptidyl-prolyl cis-trans isomerase B; peptidylprolyl isomerase B (cyclophilin B); PPIase; PPIase B; PPIB; Rotamase; Rotamase B; S-cyclophilin; SCYLP; unnamed protein product
Gene Aliases: AA408962; AA553318; AI844835; Cphn-2; Cphn2; CyP-20b; CYP-S1; CYPB; HEL-S-39; OI9; PPIB; SCYLP
UniProt ID: (Human) P23284, (Mouse) P24369
Entrez Gene ID: (Human) 5479, (Mouse) 19035
protein folding
neutrophil chemotaxis
positive regulation of multicellular organism growth
positive regulation by host of viral process
positive regulation by host of viral genome replication
protein stabilization
bone development
regulation of post-translational protein modification
protein peptidyl-prolyl isomerization
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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