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HDAC1 Monoclonal Antibody (4C4G7)

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HDAC1 Monoclonal Antibody (4C4G7)

Product Details

66085-1-IG

Applications
Tested Dilution
Publications

Western Blot (WB)

1:20,000-1:100,000
View 7 publications 7 publications

Immunohistochemistry (IHC)

-
View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500
-

Immunocytochemistry (ICC/IF)

1:50-1:500
-

ChIP assay (ChIP)

-
View 1 publication 1 publication
Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

4C4G7

Immunogen

HDAC1 Fusion Protein Ag19128 (183-482 aa encoded by BC000301)
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

150 µg

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody is raised against residues near the C terminus of human HDAC1. The calculated molecular weight of HDAC1 is 55 kDa, but modified HDAC1 is about 60-65 kDa.

Immunogen sequence: VEEAFYTTD RVMTVSFHKY GEYFPGTGDL RDIGAGKGKY YAVNYPLRDG IDDESYEAIF KPVMSKVMEM FQPSAVVLQC GSDSLSGDRL GCFNLTIKGH AKCVEFVKSF NLPMLMLGGG GYTIRNVARC WTYETAVALD TEIPNELPYN DYFEYFGPDF KLHISPSNMT NQNTNEYLEK IKQRLFENLR MLPHAPGVQM QAIPEDAIPE ESGDEDEDDP DKRISICSSD KRIACEEEFS DSEEEGEGGR KNSSNFKKAK RVKTEDEKEK DPEEKKEVTE EEKTKEEKPE AKGVKEEVKL A (183-482 aa encoded by BC000301)

Target Information

Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. HDAC1 belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, HDAC1 deacetylates p53 and modulates its effect on cell growth and apoptosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: DKFZp686H12203; HD1; HDAC1; Histone deacetylase 1; Protein deacetylase HDAC1; Protein deacylase HDAC1; protein decrotonylase HDAC1; reduced potassium dependency, yeast homolog-like 1; RP4-811H24.2; unnamed protein product

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Gene Aliases: GON-10; HD1; HDAC1; Hdac1-ps; KDAC1; MommeD5; RPD3; RPD3L1

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UniProt ID: (Human) Q13547, (Mouse) O09106, (Rat) Q4QQW4

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Entrez Gene ID: (Human) 3065, (Mouse) 433759, (Rat) 297893

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Function(s)
transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II core promoter sequence-specific DNA binding core promoter sequence-specific DNA binding transcription corepressor binding p53 binding DNA binding chromatin binding transcription corepressor activity histone deacetylase activity protein binding hydrolase activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides enzyme binding nucleosomal DNA binding protein deacetylase activity Krueppel-associated box domain binding histone deacetylase binding metal ion binding NF-kappaB binding RNA polymerase II sequence-specific DNA binding transcription factor binding E-box binding DNA-binding transcription factor binding histone deacetylase activity, hydrolytic mechanism protein decrotonylase activity histone decrotonylase activity protein lysine delactylase activity promoter-specific chromatin binding RNA polymerase II distal enhancer sequence-specific DNA binding core promoter binding RNA polymerase II repressing transcription factor binding RNA polymerase II transcription corepressor activity transcription factor activity, sequence-specific DNA binding transcription factor binding deacetylase activity histone deacetylase activity (H3-K14 specific) NAD-dependent histone deacetylase activity (H3-K14 specific) histone deacetylase activity (H3-K9 specific) protein complex binding activating transcription factor binding histone deacetylase activity (H4-K16 specific) transcription regulatory region DNA binding NAD-dependent histone deacetylase activity (H3-K9 specific) NAD-dependent histone deacetylase activity (H4-K16 specific) protein N-terminus binding repressing transcription factor binding NAD-dependent histone deacetylase activity (H3-K18 specific)
Process(es)
negative regulation of transcription from RNA polymerase II promoter response to amphetamine transcription, DNA-templated regulation of transcription, DNA-templated transcription from RNA polymerase II promoter protein deacetylation endoderm development circadian rhythm positive regulation of cell proliferation negative regulation of cell proliferation epidermal cell differentiation negative regulation of gene expression positive regulation of receptor biosynthetic process chromatin modification histone deacetylation hippocampus development neuron differentiation positive regulation of interleukin-1 production positive regulation of tumor necrosis factor production circadian regulation of gene expression cellular response to oxidative stress odontogenesis of dentin-containing tooth positive regulation of tyrosine phosphorylation of Stat3 protein embryonic digit morphogenesis ATP-dependent chromatin remodeling negative regulation of apoptotic process negative regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of neuron apoptotic process negative regulation by host of viral transcription negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter negative regulation of insulin secretion rhythmic process positive regulation of oligodendrocyte differentiation negative regulation of androgen receptor signaling pathway hair follicle placode formation eyelid development in camera-type eye fungiform papilla formation histone H3 deacetylation histone H4 deacetylation negative regulation of canonical Wnt signaling pathway positive regulation of chemokine (C-X-C motif) ligand 2 production positive regulation of type B pancreatic cell apoptotic process negative regulation of peptidyl-lysine acetylation negative regulation of intrinsic apoptotic signaling pathway chromatin organization chromatin remodeling methylation-dependent chromatin silencing regulation of transcription from RNA polymerase II promoter positive regulation of gene expression negative regulation of myotube differentiation negative regulation of cell migration negative regulation of transforming growth factor beta receptor signaling pathway heterochromatin assembly positive regulation of intracellular estrogen receptor signaling pathway cellular response to platelet-derived growth factor stimulus regulation of cell fate specification negative regulation of gene expression, epigenetic positive regulation of smooth muscle cell proliferation oligodendrocyte differentiation negative regulation of stem cell population maintenance positive regulation of stem cell population maintenance regulation of stem cell differentiation response to caffeine response to lipopolysaccharide response to drug response to hyperoxia cellular response to tumor necrosis factor
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