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Proteintech
Melanophilin Monoclonal Antibody (1A8D12)
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Product Details
66092-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Pig
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1A8D12
Immunogen
Melanophilin Fusion Protein Ag19286 (8-236 aa encoded by BC001653)
Conjugate
Form
Liquid
Concentration
0.77 mg/mL
Purification
Protein G
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: SKLTDEEAQ HVLEVVQRDF DLRRKEEERL EALKGKIKKE SSKRELLSDT AHLNETHCAR CLQPYQLLVN SKRQCLECGL FTCKSCGRVH PEEQGWICDP CHLARVVKIG SLEWYYEHVK ARFKRFGSAK VIRSLHGRLQ GGAGPELISE ERSGDSDQTD EDGEPGSEAQ AQAQPFGSKK KRLLSVHDFD FEGDSDDSTQ PQGHSLHLSS VPEARDSPQS LTDESCSEKA (8-236 aa encoded by BC001653)
Target Information
Slac2-a (for synaptotagmin-like protein (Slp) homolog lacking C2 domains-a) links Rab27A on melanosomes with Myosin VA in melanocytes. Slac2-a binds Myosin VA through a C-terminal region and GTP-bound Rab27A through its synaptotagmin-like protein homology domain (SHD), which is located near the N-terminus. The transport of pigment and cytotoxic granules in melanocytes requires the stable formation of this complex, and thus mutations in the binding domains of the three protein components may cause albinism and/or severe immune disorders.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Exophilin-3; leaden; Melanophilin; MGC2771; MGC59733; OTTMUSP00000025451; SlaC2-a; Slp homolog lacking C2 domains a; Synaptotagmin-like protein 2a; synaptotagmin-like protein homologue lacking C2 domains-a; unnamed protein product
Gene Aliases: MLPH; SLAC2-A; SLAC2A
UniProt ID: (Human) Q9BV36
Entrez Gene ID: (Human) 79083, (Pig) 100049680
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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