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Proteintech
Caspase 9/p35/p10 Monoclonal Antibody (1B7G2)
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Product Details
66169-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
1B7G2
Immunogen
Caspase 9/p35/p10 Fusion Protein Ag20813 (141-392 aa encoded by BC002452)
Conjugate
Form
Liquid
Concentration
1.5 mg/mL
Amount
225 µg
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: ALESLRGNA DLAYILSMEP CGHCLIINNV NFCRESGLRT RTGSNIDCEK LRRRFSSLHF MVEVKGDLTA KKMVLALLEL AQQDHGALDC CVVVILSHGC QASHLQFPGA VYGTDGCPVS VEKIVNIFNG TSCPSLGGKP KLFFIQACGG EQKDHGFEVA STSPEDESPG SNPEPDATPF QEGLRTFDQL DAISSLPTPS DIFVSYSTFP GFVSWRDPKS GSWYVETLDD IFEQWAHSED LQSLLLRVAN AVS (141-392 aa encoded by BC002452)
Target Information
Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: APAF-3; apoptotic protease activating factor 3; Apoptotic protease Mch-6; Apoptotic protease-activating factor 3; CASP-9; CASP9; caspase 9, apoptosis-related cysteine peptidase; caspase 9b; Caspase-9; caspase-9 variant; ICE-LAP6; ICE-like apoptotic protease 6; protein phosphatase 1, regulatory subunit 56; unnamed protein product
Gene Aliases: AI115399; APAF-3; APAF3; AW493809; CASP-9; CASP9; Caspase-9; ICE-LAP6; MCH6; PPP1R56
UniProt ID: (Human) P55211, (Mouse) Q8C3Q9
Entrez Gene ID: (Human) 842, (Mouse) 12371
cysteine-type endopeptidase activity
protein binding
enzyme activator activity
peptidase activity
cysteine-type peptidase activity
hydrolase activity
protein kinase binding
identical protein binding
SH3 domain binding
cysteine-type endopeptidase activity involved in apoptotic signaling pathway
protease
response to hypoxia
kidney development
response to ischemia
proteolysis
apoptotic process
cellular response to DNA damage stimulus
intrinsic apoptotic signaling pathway in response to DNA damage
response to UV
protein processing
platelet formation
response to cobalt ion
response to estradiol
response to lipopolysaccharide
glial cell apoptotic process
cellular response to UV
signal transduction in response to DNA damage
regulation of apoptotic process
positive regulation of apoptotic process
positive regulation of neuron apoptotic process
fibroblast apoptotic process
neuron apoptotic process
protein maturation
cellular response to dexamethasone stimulus
response to indole-3-methanol
leukocyte apoptotic process
response to anesthetic
intrinsic apoptotic signaling pathway
positive regulation of execution phase of apoptosis
epithelial cell apoptotic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
response to organic cyclic compound
regulation of response to DNA damage stimulus
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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