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Proteintech
P62/SQSTM1 Monoclonal Antibody (1H5C1)
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Product Details
66184-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
1H5C1
Immunogen
P62/SQSTM1 Fusion Protein Ag13131 (1-440 aa encoded by BC017222)
Conjugate
Form
Liquid
Concentration
1.33 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
The molecular weight of p62 is predicted as 48/ 38 kDa, while western blot analyses using this antibody demonstrate the major band around 60-62 kDa in various tissues.
Immunogen sequence: MASLTVKAY LLGKEDAARE IRRFSFCCSP EPEAEAEAAA GPGPCERLLS RVAALFPALR PGGFQAHYRD EDGDLVAFSS DEELTMAMSY VKDDIFRIYI KEKKECRRDH RPPCAQEAPR NMVHPNVICD GCNGPVVGTR YKCSVCPDYD LCSVCEGKGL HRGHTKLAFP SPFGHLSEGF SHSRWLRKVK HGHFGWPGWE MGPPGNWSPR PPRAGEARPG PTAESASGPS EDPSVNFLKN VGESVAAALS PLGIEVDIDV EHGGKRSRLT PVSPESSSTE EKSSSQPSSC CSDPSKPGGN VEGATQSLAE QMRKIALESE GRPEEQMESD NCSGGDDDWT HLSSKEVDPS TGELQSLQMP ESEGPSSLDP SQEGPTGLKE AALYPHLPPE ADPRLIESLS QMLSMGFSDE GGWLTRLLQT KNYDIGAALD TIQYSKHPPP L (1-440 aa encoded by BC017222)
Target Information
This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: autophagy receptor p62; EBI3-associated protein of 60 kDa; EBI3-associated protein p60; EBIAP; oxidative stress induced like; p62; p62 transcript variant 4; p62 transcript variant 5; phosphotyrosine independent ligand for the Lck SH2 domain p62; Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa; Sequestosome-1; Ubiquitin-binding protein p62; unnamed protein product
Gene Aliases: A170; DMRV; EBIAP; FTDALS3; NADGP; ORCA; OSIL; p60; p62; p62B; PDB3; SQSTM1; ZIP3
UniProt ID: (Human) Q13501
Entrez Gene ID: (Human) 8878
protein kinase C binding
protein binding
zinc ion binding
enzyme binding
protein kinase binding
protein binding, bridging
receptor tyrosine kinase binding
ubiquitin protein ligase binding
ionotropic glutamate receptor binding
signaling receptor activity
SH2 domain binding
identical protein binding
ubiquitin binding
macromolecular complex binding
metal ion binding
K63-linked polyubiquitin binding
ubiquitin-dependent protein binding
protein sequestering activity
molecular sequestering activity
molecular condensate scaffold activity
negative regulation of transcription from RNA polymerase II promoter
mitophagy
mitophagy
pexophagy
temperature homeostasis
immune system process
response to ischemia
transcription from RNA polymerase II promoter
ubiquitin-dependent protein catabolic process
protein import into nucleus
autophagy
apoptotic process
endosome organization
protein localization
positive regulation of autophagy
regulation of mitochondrion organization
endosomal transport
macroautophagy
cell differentiation
protein catabolic process
negative regulation of protein ubiquitination
cellular response to stress
toll-like receptor 4 signaling pathway
negative regulation of toll-like receptor 4 signaling pathway
intracellular signal transduction
aggrephagy
positive regulation of apoptotic process
regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of transcription from RNA polymerase II promoter
regulation of Ras protein signal transduction
regulation of protein complex stability
brown fat cell proliferation
protein K63-linked ubiquitination
protein targeting to vacuole involved in autophagy
energy homeostasis
response to mitochondrial depolarisation
negative regulation of ferroptosis
membraneless organelle assembly
positive regulation of long-term synaptic potentiation
positive regulation of protein localization to plasma membrane
protein localization to perinuclear region of cytoplasm
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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