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Proteintech
Cytochrome c Monoclonal Antibody (2D8D11)
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Product Details
66264-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
2D8D11
Immunogen
Cytochrome c Fusion Protein Ag24349 (1-105 aa encoded by BC009578)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MGDVEKGKK IFIMKCSQCH TVEKGGKHKT GPNLHGLFGR KTGQAPGYSY TAANKNKGII WGEDTLMEYL ENPKKYIPGT KMIFVGIKKK EERADLIAYL KKATNE (1-105 aa encoded by B C009578)
Target Information
Cytochrome C is an electron transporting protein that resides within the intermembrane space of the mitochondria, where it plays a critical role in oxidative phosphorylation and the production of cellular ATP. Release of cytochrome C from the mitochondria to the cytosol is triggered by apoptotic stimuli. In the cytoplasm, the cytochrome C binds apoptotic protease activating factor which activates the apoptotic initiator procaspase 9. Cytosolic cytochrome C functions in the activation of caspase 3, an ICE family molecule that is a key effector of apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CRF; CYCS; Cytochrome c; Cytochrome C, expressed in somatic tissues; Cytochrome c, somatic; hc1; unnamed protein product
Gene Aliases: CYC; CYCS; CYCSA; HCS; THC4
UniProt ID: (Human) P99999, (Mouse) P62897, (Rat) P62898
Entrez Gene ID: (Human) 54205, (Mouse) 13063, (Rat) 25309
mitochondrial electron transport, ubiquinol to cytochrome c
mitochondrial electron transport, cytochrome c to oxygen
apoptotic process
cellular respiration
apoptotic signaling pathway
intrinsic apoptotic signaling pathway
execution phase of apoptosis
apoptotic DNA fragmentation
activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
hydrogen peroxide metabolic process
ATP synthesis coupled electron transport
response to ischemia
response to oxidative stress
negative regulation of hydrogen peroxide biosynthetic process
glial cell apoptotic process
positive regulation of cellular respiration
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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