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Proteintech
GLUT1 Monoclonal Antibody (2A5A2)
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Product Details
66290-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human,
Mouse
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
2A5A2
Immunogen
GLUT1 Fusion Protein Ag17108 (216-280 aa encoded by BC121804)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
150 µg
Purification
Protein G
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
66290-1-Ig antibody can detect the 130 kDa dimer protein in SDS-PAGE.
Immunogen sequence: INRNEENRA KSVLKKLRGT ADVTHDLQEM KEESRQMMRE KKVTILELFR SPAYRQPILI AVVLQL (216-280 aa encoded by BC121804)
Target Information
Glucose transporter 1 (GLUT1), encoded by the SLC2A1 gene, is a facilitative glucose transporter that plays a pivotal role in the uptake of glucose across cell membranes, particularly in tissues with high-energy demands such as the brain, erythrocytes, and endothelial cells of the blood-brain barrier. GLUT1 is ubiquitously expressed and functions through a passive diffusion mechanism, allowing glucose to move down its concentration gradient. Its involvement in maintaining glucose homeostasis is crucial for cellular metabolism and energy production. Mutations in SLC2A1 can lead to GLUT1 deficiency syndrome, characterized by seizures, developmental delay, and movement disorders due to impaired glucose transport into the brain. GLUT1 also plays a significant role in cancer biology, where its overexpression is commonly observed in various tumors, facilitating the enhanced glucose uptake required for rapid tumor cell proliferation. This characteristic makes GLUT1 a potential target for cancer diagnostics and therapeutics. Additionally, GLUT1's regulation is influenced by factors such as hypoxia, insulin, and cellular stress, highlighting its adaptive role in different physiological and pathological states.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: choreoathetosis/spasticity, episodic (paroxysmal choreoathetosis/spasticity); dystonia gene 18; dystonia gene 9; glucose transporter glut1; glucose transporter glycoprotein; Glucose transporter type 1, erythrocyte/brain; GLUT-1; GT1; HepG2 glucose transporter; human T-cell leukemia virus (I and II) receptor; MGC141895; MGC141896; receptor for HTLV-1 and HTLV-2; solute carrier family 2 (facilitated glucose transporter), member 1; Solute carrier family 2, facilitated glucose transporter member 1; solute carrier family 2, member 1; unnamed protein product
Gene Aliases: CSE; DYT17; DYT18; DYT9; EIG12; GLUT; GLUT-1; GLUT1; GLUT1DS; HTLVR; PED; SDCHCN; SLC2A1
UniProt ID: (Human) P11166, (Mouse) P17809
Entrez Gene ID: (Human) 6513, (Mouse) 20525
long-chain fatty acid transporter activity
protein binding
fucose transmembrane transporter activity
kinase binding
transmembrane transporter activity
dehydroascorbic acid transporter activity
identical protein binding
xenobiotic transporter activity
D-glucose transmembrane transporter activity
transporter activity
sugar:proton symporter activity
glucose transmembrane transporter activity
substrate-specific transmembrane transporter activity
protein self-association
response to hypoxia
central nervous system development
female pregnancy
fucose transmembrane transport
plasma membrane long-chain fatty acid transport
L-ascorbic acid metabolic process
cerebral cortex development
response to insulin
cellular response to glucose starvation
xenobiotic transport
photoreceptor cell maintenance
glucose import
transmembrane transport
protein-containing complex assembly
dehydroascorbic acid transport
cellular response to mechanical stimulus
cellular hyperosmotic response
glucose import across plasma membrane
transport across blood-brain barrier
response to Thyroglobulin triiodothyronine
glucose transmembrane transport
protein complex assembly
transport
carbohydrate transport
glucose transport
proton transport
hexose transmembrane transport
cation transmembrane transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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