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Proteintech
TRAF3 Monoclonal Antibody (1E3F4)
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Product Details
66310-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
1E3F4
Immunogen
TRAF3 Fusion Protein Ag12185 (6-351 aa encoded by BC075087)
Conjugate
Form
Liquid
Concentration
2 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: KMDSPGALQ TNPPLKLHTD RSAGTPVFVP EQGGYKEKFV KTVEDKYKCE KCHLVLCSPK QTECGHRFCE SCMAALLSSS SPKCTACQES IVKDKVFKDN CCKREILALQ IYCRNESRGC AEQLMLGHLL VHLKNDCHFE ELPCVRPDCK EKVLRKDLRD HVEKACKYRE ATCSHCKSQV PMIALQKHED TDCPCVVVSC PHKCSVQTLL RSELSAHLSE CVNAPSTCSF KRYGCVFQGT NQQIKAHEAS SAVQHVNLLK EWSNSLEKKV SLLQNESVEK NKSIQSLHNQ ICSFEIEIER QKEMLRNNES KILHLQRVID SQAEKLKELD KEIRPFRQNW EEADSMK (6-351 aa encoded by BC075087)
Target Information
Tumor necrosis factor (TNF) induced signaling is mediated through association of TNF receptor (TNFR) with adaptor proteins, such as TNF receptor associated proteins (TRAFs). TRAFs form a family of cytoplasmic adapter proteins that mediate signal transduction from many members of the TNF-receptor superfamily (e. g. RANK, CD30, CD40, etc. ) and the interleukin-1 receptor. The carboxy-terminal region of TRAFs is required for self-association and interaction with receptor cytoplasmic domains following ligand-induced oligomerization. Recent molecular cloning studies have lead to identification of six TRAFs (TRAF1-TRAF6). TRAF3, originally named CRAF1, interacts directly with the CD40 cytoplasmic tail through a region of similarity to the tumor necrosis factor-alpha (TNF-alpha) receptor-associated factors. TRAF3 binds only a single site, which contains the sequence PEQET, whereas TRAF1 and TRAF2 are capable of binding to either the PEQET site or an additional downstream domain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CD40 associated protein 1; CD40 binding protein; CD40 receptor associated factor 1; CD40 receptor-associated factor 1; CD40-binding protein; CD40BP; CRAF1; LAP1; LMP1-associated protein 1; RING-type E3 ubiquitin transferase TRAF3; TNF receptor-associated factor 3; TRAFAMN
Gene Aliases: AI528849; amn; CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1; T-BAM; TRAF3; TRAFAMN
UniProt ID: (Human) Q13114, (Mouse) Q60803
Entrez Gene ID: (Human) 7187, (Mouse) 22031
ubiquitin-protein transferase activity
signal transducer activity
tumor necrosis factor receptor binding
protein binding
zinc ion binding
ligase activity
protein kinase binding
protein phosphatase binding
ubiquitin protein ligase binding
thioesterase binding
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity
ribosomal S6-glutamic acid ligase activity
coenzyme F420-0 gamma-glutamyl ligase activity
coenzyme F420-2 alpha-glutamyl ligase activity
metal ion binding
protein-glycine ligase activity
protein-glycine ligase activity, initiating
protein-glycine ligase activity, elongating
tubulin-glycine ligase activity
protein-glutamic acid ligase activity
tubulin-glutamic acid ligase activity
scaffold/adaptor protein
regulation of cytokine production
toll-like receptor signaling pathway
apoptotic process
signal transduction
Toll signaling pathway
protein ubiquitination
regulation of proteolysis
negative regulation of NF-kappaB transcription factor activity
negative regulation of type I interferon production
regulation of interferon-beta production
tumor necrosis factor-mediated signaling pathway
TRIF-dependent toll-like receptor signaling pathway
regulation of apoptotic process
innate immune response
regulation of defense response to virus
immune system process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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