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Proteintech
RAB5A Monoclonal Antibody (1B6A5)
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Product Details
66339-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Pig
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
1B6A5
Immunogen
RAB5A Fusion Protein Ag16781 (1-215 aa encoded by BC001267)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MASRGATRP NGPNTGNKIC QFKLVLLGES AVGKSSLVLR FVKGQFHEFQ ESTIGAAFLT QTVCLDDTTV KFEIWDTAGQ ERYHSLAPMY YRGAQAAIVV YDITNEESFA RAKNWVKELQ RQASPNIVIA LSGNKADLAN KRAVDFQEAQ SYADDNSLLF METSAKTSMN VNEIFMAIAK KLPKNEPQNP GANSARGRGV DLTEPTQPTR NQCCSN (1-215 aa encoded by B C001267)
Target Information
RAB5 are among the small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes. Contributes to the regulation of filopodia extension. Required for the exosomal release of SDCBP, CD63, PDCD6IP and syndecan. Regulates maturation of apoptotic cell-containing phagosomes, probably downstream of DYN2 and PIK3C3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Rab 5; Rab 5A; RAB5A; Ras related protein; RAS-associated protein RAB5A; Ras-related protein Rab-5A; unnamed protein product
Gene Aliases: RAB5; RAB5A
UniProt ID: (Human) P20339, (Pig) Q06AU6
Entrez Gene ID: (Human) 5868, (Pig) 100144499
intracellular protein transport
endocytosis
phagocytosis
protein transport
endosomal transport
receptor internalization
synaptic vesicle recycling
modulation by host of viral process
early endosome to late endosome transport
positive regulation of exocytosis
regulation of long-term neuronal synaptic plasticity
plasma membrane to endosome transport
regulation of endosome size
regulation of filopodium assembly
canonical Wnt signaling pathway
membrane fusion
amyloid-beta clearance by transcytosis
protein localization to early endosome
regulation of synaptic vesicle exocytosis
regulation of autophagosome assembly
viral RNA genome replication
receptor internalization involved in canonical Wnt signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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