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Proteintech
Annexin A1 Monoclonal Antibody (1E1B7)
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Product Details
66344-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1E1B7
Immunogen
Annexin A1 Fusion Protein Ag17273 (1-346 aa encoded by BC001275)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
150 µg
Purification
Protein G
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MAMVSEFLK QAWFIENEEQ EYVQTVKSSK GGPGSAVSPY PTFNPSSDVA ALHKAIMVKG VDEATIIDIL TKRNNAQRQQ IKAAYLQETG KPLDETLKKA LTGHLEEVVL ALLKTPAQFD ADELRAAMKG LGTDEDTLIE ILASRTNKEI RDINRVYREE LKRDLAKDIT SDTSGDFRNA LLSLAKGDRS EDFGVNEDLA DSDARALYEA GERRKGTDVN VFNTILTTRS YPQLRRVFQK YTKYSKHDMN KVLDLELKGD IEKCLTAIVK CATSKPAFFA EKLHQAMKGV GTRHKALIRI MVSRSEIDMN DIKAFYQKMY GISLCQAILD ETKGDYEKIL VALCGGN (1-346 aa encoded by BC001275)
Target Information
Annexin I belongs to a family of Ca (2+) -dependent phospholipid binding proteins that are preferentially located on the cytosolic face of the plasma membrane. Annexin I has a molecular mass of 40 kDa, with phospholipase A2 inhibitory activity. Since phospholipase A2 is required for the biosynthesis of the potent mediators of inflammation, prostaglandins and leukotrienes, annexin I may have potential anti-inflammatory activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ANAX1; Annexin A1; Annexin I; annexin I (lipocortin I); Annexin-1; ANXA1; Calpactin II; Calpactin-2; Chromobindin-9; epididymis secretory sperm binding protein; lipocortin 1; Lipocortin I; p35; Phospholipase A2 inhibitory protein; RP11-71A24.1; unnamed protein product
Gene Aliases: Anx-1; Anx-A1; ANX1; ANXA1; C430014K04Rik; Lpc-1; LPC1
UniProt ID: (Human) P04083, (Mouse) P10107
Entrez Gene ID: (Human) 301, (Mouse) 16952
phosphatidylserine binding
phospholipase inhibitor activity
receptor binding
calcium ion binding
protein binding
phospholipid binding
calcium-dependent phospholipid binding
lipid binding
phospholipase A2 inhibitor activity
metal ion binding
calcium-dependent protein binding
cadherin binding involved in cell-cell adhesion
single-stranded DNA binding
single-stranded RNA binding
helicase activity
structural molecule activity
protein binding, bridging
double-stranded DNA-dependent ATPase activity
annealing helicase activity
protein homodimerization activity
calcium-binding protein
neutrophil homeostasis
adaptive immune response
immune system process
monocyte chemotaxis
regulation of leukocyte migration
phagocytosis
inflammatory response
signal transduction
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
regulation of cell shape
myoblast migration involved in skeletal muscle regeneration
peptide cross-linking
actin cytoskeleton organization
keratinocyte differentiation
positive regulation of vesicle fusion
regulation of interleukin-1 production
negative regulation of interleukin-8 production
positive regulation of interleukin-2 production
positive regulation of neutrophil apoptotic process
cellular response to vascular endothelial growth factor stimulus
positive regulation of T cell proliferation
neutrophil activation
regulation of cell proliferation
negative regulation of apoptotic process
innate immune response
positive regulation of T-helper 1 cell differentiation
negative regulation of T-helper 2 cell differentiation
negative regulation of exocytosis
alpha-beta T cell differentiation
regulation of hormone secretion
arachidonic acid secretion
regulation of inflammatory response
negative regulation of transport
positive regulation of multicellular organismal process
cellular response to glucocorticoid stimulus
granulocyte chemotaxis
positive regulation of cell migration involved in sprouting angiogenesis
positive regulation of wound healing
neutrophil clearance
cell-cell adhesion
positive regulation of G1/S transition of mitotic cell cycle
DNA strand renaturation
insulin secretion
positive regulation of prostaglandin biosynthetic process
DNA duplex unwinding
DNA rewinding
positive regulation of apoptotic process
negative regulation of protein secretion
cellular response to hydrogen peroxide
prolactin secretion
negative regulation of phospholipase A2 activity
negative regulation of interleukin-8 secretion
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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