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Proteintech
BRE Monoclonal Antibody (2E5A5)
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Product Details
66356-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
2E5A5
Immunogen
BRE Fusion Protein Ag2256 (94-383 aa encoded by BC001251)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
150 µg
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: PDPSALQNL ASWNPSNPEC LLLVVKELVQ QYHQFQCSRL RESSRLMFEY QTLLEEPQYG ENMEIYAGKK NNWTGEFSAR FLLKLPVDFS NIPTYLLKDV NEDPGEDVAL LSVSFEDTEA TQVYPKLYLS PRIEHALGGS SALHIPAFPG GGCLIDYVPQ VCHLLTNKVQ YVIQGYHKRR EYIAAFLSHF GTGVVEYDAE GFTKLTLLLM WKDFCFLVHI DLPLFFPRDQ PTLTFQSVYH FTNSGQLYSQ AQKNYPYSPR WDGNEMAKRA KAYFKTFVPQ FQEAAFANGK L (94-383 aa encoded by BC001251)
Target Information
BRCC45 was initially suggested to be a housekeeping protein that is highly expressed in brain and reproductive organs. Later experiments indicated BRCC45 forms a complex with the breast and ovarian predisposition proteins BRCA1 and BRCA2 as well as RAD51 and BRCC36. This complex has a ubiquitin E3 ligase activity and is thought to enhance cellular survival following DNA damage. BRCC45 has also been suggested to function as a death receptor-associated anti-apoptotic protein by inhibiting the BID-induced activation of the mitochondrial apoptotic pathway. Higher levels of BRCC45 were detected in the majority of hepatocellular carcinomas, suggesting that BRCC45 may promote tumorigenesis when overexpressed. At least three isoforms of BRCC45 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: brain and reproductive organ-expressed (TNFRSF1A modulator); Brain and reproductive organ-expressed protein; BRCA1-A complex subunit BRE; BRCA1/BRCA2-containing complex subunit 45; BRCA1/BRCA2-containing complex, subunit 4; bre; bre {ECO:0000312|RGD:735111}; BRISC and BRCA1-A complex member 2; putative redox regulating protein; unnamed protein product
Gene Aliases: 6030405P19Rik; AI429776; B830038C02Rik; BABAM2; BRCC4; BRCC45; BRE
UniProt ID: (Human) Q9NXR7, (Mouse) Q8K3W0, (Rat) Q6P7Q1
Entrez Gene ID: (Human) 9577, (Mouse) 107976, (Rat) 362704
DNA repair
double-strand break repair
apoptotic process
cellular response to DNA damage stimulus
response to ionizing radiation
chromatin modification
G2 DNA damage checkpoint
positive regulation of DNA repair
regulation of DNA repair
chromatin organization
mitotic G2 DNA damage checkpoint
signal transduction
negative regulation of apoptotic process
mitotic G2/M transition checkpoint
cell division
protein K63-linked deubiquitination
cellular response to ionizing radiation
regulation of DNA damage checkpoint
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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