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Proteintech
D2HGDH Monoclonal Antibody (1E9B3)
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Product Details
66364-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1E9B3
Immunogen
D2HGDH Fusion Protein Ag5036 (1-286 aa encoded by BC036604)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein G
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MLPRRPLAW PAWLLRGAPG AAGSWGRPVG PLARRGCCSA PGTPEVPLTR ERYPVQRLPF STVSKQDLAA FERIVPGGVV TDPEALQAPN VDWLRTLRGC SKVLLRPRTS EEVSHILRHC HERNLAVNPQ GGNTGMVGGS VPVFDEIILS TARMNRVLSF HSVSGILVCQ AGCVLEELSR YVEERDFIMP LDLGAKGSCH IGGNVATNAG GLRFLRYGSL HGTVLGLEVV LADGTVLDCL TSLRKDNTGY DLKQLFIGSE GTLGIITTVS ILCPPKPRAV NVAFLGC (1-286 aa encoded by BC036604)
Target Information
This gene encodes D-2hydroxyglutarate dehydrogenase, a mitochondrial enzyme belonging to the FAD-binding oxidoreductase/transferase type 4 family. This enzyme, which is most active in liver and kidney but also active in heart and brain, converts D-2-hydroxyglutarate to 2-ketoglutarate. Mutations in this gene are present in D-2-hydroxyglutaric aciduria, a rare recessive neurometabolic disorder causing developmental delay, epilepsy, hypotonia, and dysmorphic features.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: D-2-hydroxyglutarate dehydrogenase, mitochondrial; FLJ42195; MGC25181; unnamed protein product
Gene Aliases: AA408776; AA408778; AI325464; D2HGD; D2HGDH
UniProt ID: (Human) Q8N465, (Mouse) Q8CIM3
Entrez Gene ID: (Human) 728294, (Mouse) 98314
catalytic activity
zinc ion binding
oxidoreductase activity
metal ion binding
flavin adenine dinucleotide binding
(R)-2-hydroxyglutarate dehydrogenase activity
FAD binding
UDP-N-acetylmuramate dehydrogenase activity
oxidoreductase activity, acting on CH-OH group of donors
limonene-1,2-diol dehydrogenase activity
dehydrogenase
oxidoreductase
metabolite interconversion enzyme
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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