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Proteintech
ZC3HAV1 Monoclonal Antibody (1G10B9)
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Product Details
66413-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1G10B9
Immunogen
ZC3HAV1 Fusion Protein Ag10364 (1-351 aa encoded by BC025308)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
150 µg
Purification
Protein G
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MADPEVCCF ITKILCAHGG RMALDALLQE IALSEPQLCE VLQVAGPDRF VVLETGGEAG ITRSVVATTR ARVCRRKYCQ RPCDNLHLCK LNLLGRCNYS QSERNLCKYS HEVLSEENFK VLKNHELSGL NKEELAVLLL QSDPFFMPEI CKSYKGEGRQ QICNQQPPCS RLHICDHFTR GNCRFPNCLR SHNLMDRKVL AIMREHGLNP DVVQNIQDIC NSKHMQKNPP GPRAPSSHRR NMAYRARSKS RDRFFQGSQE FLASASASAE RSCTPSPDQI SHRASLEDAP VDDLTRKFTY LGSQDRARPP SGSSKATDLG GTSQAGTSQR FLENGSQEDL LHGNPGSTYL AS (1-351 aa encoded by BC025308)
Target Information
The zinc finger antiviral protein (ZC3HAV1) is a CCCH type zinc finger protein that induces an innate immunity to infections by retrovirus by preventing the accumulation of viral RNAs in the cytoplasm and recruits the RNA processing exosome to degrade target RNAs, thereby inhibiting virus replication. ZC3HAV1 is localized in the cytoplasm at steady state, but shuttles between nucleus and cytoplasm in a XPO1-dependent manner. ZAP is a direct target gene of IRF3 action in cellular antiviral responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ADP-ribosyltransferase diphtheria toxin-like 13; ARTD13; Inactive Poly [ADP-ribose] polymerase 13; PARP13; predicted protein of HQ1677; unnamed protein product; ZAP; Zinc finger antiviral protein; Zinc finger CCCH domain-containing protein 2; Zinc finger CCCH-type antiviral protein 1; zinc finger CCCH-type, antiviral 1
Gene Aliases: ARTD13; FLB6421; PARP13; PRO1677; ZAP; ZC3H2; ZC3HAV1; ZC3HDC2
UniProt ID: (Human) Q7Z2W4
Entrez Gene ID: (Human) 56829
immune system process
response to virus
positive regulation of type I interferon production
positive regulation of interferon-alpha production
positive regulation of interferon-beta production
positive regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of viral genome replication
innate immune response
defense response to virus
positive regulation of mRNA catabolic process
protein poly-ADP-ribosylation
positive regulation of RIG-I signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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