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Proteintech
ZO-1 Monoclonal Antibody (1G4A1)
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Product Details
66452-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Dog,
Human
Published species
Human,
Mouse
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1G4A1
Immunogen
ZO-1 Fusion Protein Ag16454 (1446-1748 aa encoded by BC111712)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: SLHIHSKGA HGEGNSVSLD FQNSLVSKPD PPPSQNKPAT FRPPNREDTA QAAFYPQKSF PDKAPVNGTE QTQKTVTPAY NRFTPKPYTS SARPFERKFE SPKFNHNLLP SETAHKPDLS SKTPTSPKTL VKSHSLAQPP EFDSGVETFS IHAEKPKYQI NNISTVPKAI PVSPSAVEED EDEDGHTVVA TARGIFNSNG GVLSSIETGV SIIIPQGAIP EGVEQEIYFK VCRDNSILPP LDKEKGETLL SPLVMCGPHG LKFLKPVELR LPHCDPKTWQ NKCLPGDPNY LVGANCVSVL IDHF (1446-1748 aa encoded by BC111712)
Target Information
ZO-1 forms complexes with either ZO-2 or ZO-3. In addition, these proteins can also associate with claudin, occludin and F-actin, at tight junction stands, where they provide a linkage between the actin cytoskeleton and the tight junction. ZO-1 expression is significantly reduced in many breast cancer lines. ZO-2 and ZO-3 are ubiquitously expressed within epithelial tight junctions, and unlike ZO-1, which is also expressed at cell junctions of cardiac myocytes, ZO-2 is not expressed in nonepithelial tissue. ZO-1 is a protein located on a cytoplasmic membrane surface of intercellular tight junctions. ZO-1 may be involved in signal transduction at cell-cell junctions. Two transcript variants encoding distinct isoforms have been identified for the ZO-1 gene. Diseases associated with ZO-1 dysfunction include Celiac Disease and Congenital Nephrotic Syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: DKFZp686M05161; MGC133289; OTTHUMP00000174520; Tight junction protein 1; tight junction protein 1 (zona occludens 1); Tight junction protein ZO-1; unnamed protein product; zona occludens 1; Zona occludens protein 1; zonula occludens 1 protein; Zonula occludens protein 1
Gene Aliases: TJP1; ZO-1; ZO1
UniProt ID: (Human) Q07157, (Dog) O97758
Entrez Gene ID: (Human) 7082, (Dog) 403752
cell-cell junction assembly
positive regulation of cell proliferation
actin cytoskeleton organization
positive regulation of cell migration
actomyosin structure organization
adherens junction maintenance
maintenance of blood-brain barrier
ameloblast differentiation
negative regulation of apoptotic process
cell-cell junction organization
regulation of cytoskeleton organization
negative regulation of stress fiber assembly
protein localization to adherens junction
establishment of endothelial intestinal barrier
cell-cell adhesion
protein localization to cell-cell junction
regulation of cell junction assembly
protein localization to bicellular tight junction
positive regulation of sprouting angiogenesis
positive regulation of maintenance of permeability of blood-brain barrier
positive regulation of cell-cell adhesion mediated by cadherin
regulation of bicellular tight junction assembly
bicellular tight junction assembly
cellular response to calcium ion
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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