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Proteintech
HRPT2/CDC73 Monoclonal Antibody (4B4H2)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
66490-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Pig,
Rat
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
4B4H2
Immunogen
HRPT2; CDC73 Fusion Protein ag2959 (232-531 aa encoded by BC014351)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
150 µg
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: WRTRTTILQ STGKNFSKNI FAILQSVKAR EEGRAPEQRP APNAAPVDPT LRTKQPIPAA YNRYDQERFK GKEETEGFKI DTMGTYHGMT LKSVTEGASA RKTQTPAAQP VPRPVSQARP PPNQKKGSRT PIIIIPAATT SLITMLNAKD LLQDLKFVPS DEKKKQGCQR ENETLIQRRK DQMQPGGTAI SVTVPYRVVD QPLKLMPQDW DRVVAVFVQG PAWQFKGWPW LLPDGSPVDI FAKIKAFHLK YDEVRLDPNV QKWDVTVLEL SYHKRHLDRP VFLRFWETLD RYMVKHKSHL RF (232-531 aa encoded by BC014351)
Target Information
Cdc73 is a tumor suppressor probably involved in transcriptional and post-transcriptional control pathways. Cdc73 is part of the PAF1 complex, a five-subunit protein complex composed of Paf1, Cdc73, Leo1, Rtf1 and Ctr9. PAF1 was first purified from yeast in association with RNA polymerase II and is believed to function in transcription elongation. The yeast PAF (yPAF) complex interacts with RNA polymerase II and coordinates the setting of histone marks associated with active transcription. In addition to coordinating events during transcription (initiation, promoter clearance, and elongation), hPAF also coordinates events in RNA quality control. Cdc73 may also be involved in cell cycle progression through the regulation of cyclin D1/PRAD1 expression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: cell division cycle 73 Paf1/RNA polymerase II complex component homolog (S. cerevisiae) isoform CDC73_1; cell division cycle 73 Paf1/RNA polymerase II complex component homolog (S. cerevisiae) isoform CDC73_2; cell division cycle 73 Paf1/RNA polymerase II complex component-like protein; cell division cycle 73, Paf1/RNA polymerase II complex component, homolog; cell division cycle protein 73 homolog; Familial isolated hyperparathyroidism; hyperparathyroidism 2 (with jaw tumor); hyperparathyroidism 2 protein; hyperparathyroidism 2 protein homolog; Paf1/RNA polymerase II complex component; unnamed protein product
Gene Aliases: 8430414L16Rik; C130030P16Rik; C1orf28; FIHP; HPTJT; HRPT1; HRPT2; HYX
UniProt ID: (Human) Q6P1J9, (Rat) Q4V8C8, (Mouse) Q8JZM7
Entrez Gene ID: (Pig) 100526068, (Human) 79577, (Rat) 304832, (Mouse) 214498
negative regulation of transcription from RNA polymerase II promoter
regulation of cell growth
endodermal cell fate commitment
regulation of transcription from RNA polymerase II promoter
transcription elongation from RNA polymerase II promoter
biological_process
negative regulation of cell proliferation
stem cell population maintenance
positive regulation of Wnt signaling pathway
mRNA 3'-end processing
positive regulation of mRNA 3'-end processing
protein destabilization
positive regulation of transcription elongation from RNA polymerase II promoter
negative regulation of apoptotic process
negative regulation of myeloid cell differentiation
positive regulation of transcription from RNA polymerase II promoter
negative regulation of fibroblast proliferation
negative regulation of epithelial cell proliferation
cellular response to lipopolysaccharide
positive regulation of cell cycle G1/S phase transition
negative regulation of G1/S transition of mitotic cell cycle
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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