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Proteintech
NRG1 Monoclonal Antibody (2C6D12)
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Product Details
66492-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Pig,
Rabbit,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
2C6D12
Immunogen
NRG1 Fusion Protein Ag0803 (1-225 aa encoded by BC007675)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MEIYSPDMS EVAAERSSSP STQLSADPSL DGLPAAEDMP EPQTEDGRTP GLVGLAVPCC ACLEAERLRG CLNSEKICIV PILACLVSLC LCIAGLKWVF VDKIFEYDSP THLDPGGLGQ DPIISLDATA ASALWVSSEA YTSPVSRAQS ESEVQVTVQG DKAVVSFEPS AAPTPKNRIF AFSFLPSTAP SFPSPTRNPE VRTPKSATQP QTTETNLQTA PKLSTS (1-225 aa encoded by B C007675)
Target Information
Neuregulin 1 (NRG1) was originally identified as a 44-kD glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. It is known that an extraordinary variety of different isoforms are produced from the NRG1 gene by alternative splicing. These isoforms include heregulins (HRGs), glial growth factors (GGFs) and sensory and motor neuron-derived factor (SMDF). They are tissue-specifically expressed and differ significantly in their structure. The HRG isoforms all contain immunoglobulin (Ig) and epidermal growth factor-like (EGF-like) domains. GGF and GGF2 isoforms contain a kringle-like sequence plus Ig and EGF-like domains; and the SMDF isoform shares only the EGF-like domain with other isoforms. The receptors for all NRG1 isoforms are the ERBB family of tyrosine kinase transmembrane receptors. Through interaction with ERBB receptors, NRG1 isoforms induce the growth and differentiation of epithelial, neuronal, glial, and other types of cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: acetylcholine receptor-inducing activity; glial growth factor 2; growth factor; heregulin; heregulin, alpha (45kD, ERBB2 p185-activator); neu differentiation factor; neuregulin 1; neuregulin 1 type III beta 3; NRG-1; NRG1; NRG1 class VII isoform alpha 2a; NRG1 class VII isoform alpha 2b; NRG1 class VII isoform alpha beta 2a; NRG1 class VII isoform alpha beta 3; NRG1 class VII isoform beta 2a; NRG1 class VII isoform beta 3; Pro-neuregulin-1, membrane-bound isoform; Pro-NRG1; sensory and motor neuron derived factor; type I neuregulin 1; type III neuregulin 1; unnamed protein product
Gene Aliases: 6030402G23Rik; ARIA; D230005F13Rik; GGF; GGF2; GGFII; HGL; HRG; HRG1; HRGA; HRGalpha; MST131; MSTP131; NDF; NRG1; NRG1-IT2; SMDF
UniProt ID: (Human) Q02297, (Mouse) Q6DR98
Entrez Gene ID: (Human) 3084, (Rabbit) 100008920, (Pig) 102164569, (Rat) 112400, (Mouse) 211323
transcription cofactor activity
receptor binding
cytokine activity
integrin binding
protein binding
growth factor activity
zinc ion binding
nickel cation binding
protein tyrosine kinase activator activity
transmembrane receptor protein tyrosine kinase activator activity
receptor tyrosine kinase binding
ErbB-3 class receptor binding
chemorepellent activity
receptor agonist activity
ErbB-2 class receptor binding
growth factor
ventricular trabecula myocardium morphogenesis
cell communication
transmembrane receptor protein tyrosine kinase signaling pathway
nervous system development
brain development
peripheral nervous system development
cell proliferation
positive regulation of cell proliferation
regulation of cell communication
negative regulation of cardiac muscle cell apoptotic process
neural crest cell development
regulation of signaling
cell differentiation
positive regulation of cell growth
mammary gland development
positive regulation of protein complex assembly
activation of protein kinase B activity
intracellular signal transduction
ERBB signaling pathway
ERBB2 signaling pathway
ERBB3 signaling pathway
ERBB4 signaling pathway
ERBB2-ERBB3 signaling pathway
ERBB2-ERBB4 signaling pathway
ERBB4-ERBB4 signaling pathway
wound healing
positive regulation of cell adhesion
negative regulation of transcription, DNA-templated
negative chemotaxis
negative regulation of secretion
positive regulation of developmental process
positive regulation of striated muscle cell differentiation
cardiac muscle cell differentiation
ventricular cardiac muscle cell differentiation
positive regulation of cardiac muscle cell proliferation
cardiac muscle cell myoblast differentiation
endocardial cell differentiation
regulation of biological quality
positive regulation of ERK1 and ERK2 cascade
regulation of postsynaptic neurotransmitter receptor internalization
positive regulation of peptidyl-tyrosine autophosphorylation
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
MAPK cascade
cell morphogenesis
cardiac conduction system development
activation of transmembrane receptor protein tyrosine kinase activity
synapse assembly
heart development
muscle organ development
locomotory behavior
regulation of blood pressure
glial cell differentiation
glucose transport
cell migration
glial cell fate commitment
negative regulation of protein catabolic process
myelination
regulation of protein heterodimerization activity
cellular protein complex disassembly
neurotransmitter receptor metabolic process
regulation of cell differentiation
positive regulation of protein kinase activity
positive regulation of Ras protein signal transduction
animal organ development
neuron fate commitment
positive regulation of protein kinase B signaling
positive regulation of protein tyrosine kinase activity
positive regulation of calcineurin-NFAT signaling cascade
positive regulation of cardiac muscle cell differentiation
axon ensheathment
positive regulation of myelination
oligodendrocyte differentiation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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