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Proteintech
CD40L/CD154 Monoclonal Antibody (1E6D10)
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Product Details
66502-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
1E6D10
Immunogen
CD40L/CD154 Fusion Protein Ag24941 (47-261 aa encoded by BC071754)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
150 µg
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: HRRLDKIED ERNLHEDFVF MKTIQRCNTG ERSLSLLNCE EIKSQFEGFV KDIMLNKEET KKENSFEMQK GDQNPQIAAH VISEASSKTT SVLQWAEKGY YTMSNNLVTL ENGKQLTVKR QGLYYIYAQV TFCSNREASS QAPFIASLCL KSPGRFERIL LRAANTHSSA KPCGQQSIHL GGVFELQPGA SVFVNVTDPS QVSHGTGFTS FGLLKL (47-261 aa encoded by BC071754)
Target Information
CD40 Ligand (CD40-L), or CD154, is a membrane glycoprotein and differentiation antigen expressed on the surface of T cells. The CD40 Ligand stimulates B cell proliferation and secretion of all immunoglobulin isotypes in the presence of cytokines. CD40 Ligand has been shown to induce cytokine production and tumoricidal activity in peripheral blood monocytes. It also co-stimulates proliferation of activated T cells and this is accompanied by the production of IFN-gamma, TNF-alpha, and IL-2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CD154; CD40 antigen ligand; CD40 ligand; CD40 ligand CD154; CD40-L; H-CD-40-L; M-CD-40-L; RP23-153G22.3; T-B cell-activating molecule; T-cell antigen Gp39; TNF-related activation protein; TRAP; tumor necrosis factor (ligand) superfamily member 5; tumor necrosis factor (ligand) superfamily, member 5; Tumor necrosis factor ligand superfamily member 5; unnamed protein product
Gene Aliases: CD154; CD40L; CD40LG; gp39; hCD40L; HIGM1; IGM; IMD3; T-BAM; TNFSF5; TRAP
UniProt ID: (Human) P29965, (Rat) Q9Z2V2
Entrez Gene ID: (Human) 959, (Rat) 84349
regulation of immunoglobulin production
regulation of immune system process
inflammatory response
immune response
cell communication
leukocyte cell-cell adhesion
cell surface receptor signaling pathway
integrin-mediated signaling pathway
regulation of gene expression
CD40 signaling pathway
signaling
platelet activation
B cell differentiation
T cell costimulation
positive regulation of interleukin-10 production
positive regulation of interleukin-12 production
positive regulation of interleukin-4 production
B cell proliferation
positive regulation of T cell proliferation
negative regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
isotype switching
positive regulation of NF-kappaB transcription factor activity
positive regulation of endothelial cell apoptotic process
positive regulation of extrinsic apoptotic signaling pathway
positive regulation of immune response to tumor cell
positive regulation of B cell proliferation
positive regulation of interferon-gamma production
positive regulation of MHC class II biosynthetic process
immunoglobulin secretion
regulation of immunoglobulin secretion
dendritic cell differentiation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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