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Proteintech
RIC8A Monoclonal Antibody (1E3B11)
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Product Details
66625-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1E3B11
Immunogen
RIC8A Fusion Protein Ag1593 (117-467 aa encoded by BC011821)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
150 µg
Purification
Protein G
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: QQLFQELKG VRLLTDTLEL TLGVTPEGNP PTLLPSQETE RAMEILKVLF NITLDSIKGE VDEEDAALYR HLGTLLRHCV MIATAGDRTE EFHGHAVNLL GNLPLKCLDV LLTLEPHGDS TEFMGVNMDV IRALLIFLEK RLHKTHRLKE SVAPVLSVLT ECARMHRPAR KFLKAQVLPP LRDVRTRPEV GEMLRNKLVR LMTHLDTDVK RVAAEFLFVL CSESVPRFIK YTGYGNAAGL LAARGLMAGG RPEGQYSEDE DTDTDEYKEA KASINPVTGR VEEKPPNPME GMTEEQKEHE AMKLVTMFDK LSRNRVIQPM GMSPRGHLTS LQDAMCETME QQLSSDPDSD PD (117-467 aa encoded by BC011821)
Target Information
Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex. Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Chaperone Ric-8A; heterotrimeric G protein guanine nucleotide exchange factor Ric-8A; MGC104517; MGC131931; MGC148073; MGC148074; resistance to inhibitors of cholinesterase 8 homolog; resistance to inhibitors of cholinesterase 8 homolog A; resistance to inhibitors of cholinesterase 8A; RIC8 protein; synembryn; Synembryn-A; unnamed protein product
Gene Aliases: AI114950; RIC-8; Ric-8A; RIC8; RIC8A
UniProt ID: (Human) Q9NPQ8, (Mouse) Q3TIR3, (Rat) Q80ZG1
Entrez Gene ID: (Human) 60626, (Mouse) 101489, (Rat) 293614
in utero embryonic development
vasculature development
G-protein coupled receptor signaling pathway
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
gastrulation
visual learning
response to light stimulus
cell migration involved in gastrulation
positive regulation of GTPase activity
cell-cell adhesion involved in gastrulation
basement membrane organization
regulation of G-protein coupled receptor protein signaling pathway
protein folding
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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