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Proteintech
NEK2 Monoclonal Antibody (3D7B4)
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Product Details
66632-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
3D7B4
Immunogen
NEK2 Fusion Protein Ag21476 (1-445 aa encoded by BC043502)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein G
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MPSRAEDYE VLYTIGTGSY GRCQKIRRKS DGKILVWKEL DYGSMTEAEK QMLVSEVNLL RELKHPNIVR YYDRIIDRTN TTLYIVMEYC EGGDLASVIT KGTKERQYLD EEFVLRVMTQ LTLALKECHR RSDGGHTVLH RDLKPANVFL DGKQNVKLGD FGLARILNHD TSFAKTFVGT PYYMSPEQMN RMSYNEKSDI WSLGCLLYEL CALMPPFTAF SQKELAGKIR EGKFRRIPYR YSDELNEIIT RMLNLKDYHR PSVEEILENP LIADLVADEQ RRNLERRGRQ LGEPEKSQDS SPVLSELKLK EIQLQERERA LKAREERLEQ KEQELCVRER LAEDKLARAE NLLKNYSLLK ERKFLSLASN PELLNLPSSV IKKKVHFSGE SKENIMRSEN SESQLTSKSK CKDLKKRLHA AQLRAQALSD IEKNYQLKSR QILGMR (1-445 aa encoded by B C043502)
Target Information
NEK2 is involved in cell cycle regulation and is essential for faithful chromosome segregation. NEK2 is a gene that encodes for a serine/threonine-protein kinase. This protein plays a crucial role in the regulation of mitosis and is primarily located in the centrosome. During the G1 phase, the protein is undetectable, but its levels progressively increase throughout the S phase, reaching their peak in late G2 phase. The gene has several alternatively spliced transcript variants that encode different isoforms with distinct C-termini. NEK2 is associated with several diseases, including Retinitis Pigmentosa 67 and Retinitis Pigmentosa.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: HSPK 21; NEK 2; NEK 2A; Nek2 kinase; Never in mitosis A-related kinase 2; NIMA (never in mitosis gene a)-related expressed kinase 2; NIMA (never in mitosis gene a)-related kinase 2; NIMA - related expressed kinase 2; NimA-like protein kinase 1; NIMA-related expressed kinase 2; NIMA-related kinase 2; NimA-related protein kinase 2; NLK 1; protein kinase; NIMA NEK2A-t; protein phosphatase 1, regulatory subunit 111; Serine/threonine-protein kinase Nek2; unnamed protein product
Gene Aliases: AA617254; C77054; HsPK21; NEK2; NEK2A; NLK1; PPP1R111; RP67
UniProt ID: (Human) P51955, (Mouse) O35942
Entrez Gene ID: (Human) 4751, (Rat) 114482, (Mouse) 18005
nucleotide binding
protein kinase activity
protein serine/threonine kinase activity
protein binding
ATP binding
kinase activity
transferase activity
protein phosphatase binding
metal ion binding
protein serine kinase activity
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
mitotic sister chromatid segregation
mitotic cell cycle
blastocyst development
protein phosphorylation
chromosome segregation
regulation of mitotic nuclear division
positive regulation of telomere maintenance
regulation of mitotic centrosome separation
protein autophosphorylation
spindle assembly
centrosome separation
cell division
meiotic cell cycle
regulation of attachment of spindle microtubules to kinetochore
mitotic spindle assembly
negative regulation of centriole-centriole cohesion
microtubule-based process
negative regulation of DNA binding
cell cycle
mitotic nuclear division
phosphorylation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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