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Proteintech
STK4 Monoclonal Antibody (2G11C1)
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Product Details
66663-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
2G11C1
Immunogen
STK4 Fusion Protein Ag17738 (383-451 aa encoded by BC093768)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
150 µg
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: RRDETMQPA KPSFLEYFEQ KEKENQINSF GKSVPGPLKN SSDWKIPQDG DYEFLKSWTV EDLQKRLLAL (383-451 aa encoded by BC093768)
Target Information
STK4 (MST1) is a serine/threonine kinase which may be involved in apoptosis. It is possible that this protein induces the chromatin condensation observed in this process. STK4 is a stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. It is a key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: EC 2.7.11.1; hippo homolog; kinase MST1; kinase responsive to stress 2; Mammalian STE20-like protein kinase 1; mammalian sterile 20-like 1; MST-1; Serine/threonine-protein kinase 4; Serine/threonine-protein kinase Krs-2; STE20-like kinase MST1; sterile 20-like kinase 1; TIIAC; unnamed protein product; Yeast Sps1/Ste20-related kinase 3
Gene Aliases: AI447339; AU020804; Kas-2; KRS2; MST1; STK4; YSK3
UniProt ID: (Human) Q13043, (Mouse) Q9JI11
Entrez Gene ID: (Human) 6789, (Rat) 311622, (Mouse) 58231
nucleotide binding
magnesium ion binding
protein kinase activity
protein serine/threonine kinase activity
protein binding
ATP binding
kinase activity
transferase activity
identical protein binding
protein homodimerization activity
protein serine/threonine kinase activator activity
metal ion binding
RNA polymerase II sequence-specific DNA binding transcription factor binding
protein serine kinase activity
receptor signaling protein serine/threonine kinase activity
transcription factor binding
protein dimerization activity
MAP kinase kinase kinase activity
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
cell morphogenesis
patterning of blood vessels
neural tube formation
positive regulation of protein phosphorylation
endocardium development
protein phosphorylation
protein import into nucleus
apoptotic process
signal transduction
central nervous system development
cell proliferation
negative regulation of cell proliferation
extrinsic apoptotic signaling pathway via death domain receptors
anatomical structure morphogenesis
peptidyl-serine phosphorylation
keratinocyte differentiation
positive regulation of peptidyl-serine phosphorylation
organ growth
hippo signaling
positive regulation of hippo signaling
intracellular signal transduction
positive regulation of apoptotic process
regulation of MAPK cascade
positive regulation of fat cell differentiation
negative regulation of organ growth
protein autophosphorylation
epithelial cell proliferation
negative regulation of epithelial cell proliferation
protein stabilization
protein tetramerization
canonical Wnt signaling pathway
primitive hemopoiesis
cell differentiation involved in embryonic placenta development
regulation of cell differentiation involved in embryonic placenta development
negative regulation of canonical Wnt signaling pathway
hepatocyte apoptotic process
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
positive regulation of hepatocyte apoptotic process
positive regulation of substrate-dependent cell migration, cell attachment to substrate
signal transduction by protein phosphorylation
positive regulation of protein binding
MAPK cascade
activation of MAPKK activity
regulation of mitotic cell cycle
phosphorylation
stress-activated protein kinase signaling cascade
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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