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Proteintech
EPHA2 Monoclonal Antibody (1A9C3)
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Product Details
66736-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1A9C3
Immunogen
EPHA2 Fusion Protein Ag22566
Conjugate
Form
Liquid
Concentration
1000 µg/mL
Amount
150 µg
Purification
Protein G
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Aliquoting is unnecessary for -20°C storage.
Target Information
EPHA2 belongs to the ephrin receptor subfamily of the protein tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediated developmental events, particularly in the nervous system. EPHA2 is overexpressed in many types of human cancers. The tyrosine kinase (TK) group is mainly involved in the regulation of cell-cell interactions such as differentiation, adhesion, motility and death. There are currently about 90 TK genes sequenced, 58 are of receptor protein TK (e.g. EGFR, EPH, FGFR, PDGFR, TRK, and VEGFR families), and 32 of cytosolic TK (e.g. ABL, FAK, JAK, and SRC families).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Ephrin type-A receptor 2; Epithelial cell kinase; epithelial cell receptor protein tyrosine kinase; Tyrosine-protein kinase receptor ECK; unnamed protein product
Gene Aliases: ARCC2; CTPA; CTPP1; CTRCT6; ECK; EPHA2
UniProt ID: (Human) P29317
Entrez Gene ID: (Human) 1969
nucleotide binding
virus receptor activity
protein kinase activity
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
ephrin receptor activity
protein binding
ATP binding
kinase activity
transferase activity
growth factor binding
cadherin binding
molecular function activator activity
skeletal system development
angiogenesis
blood vessel development
vasculogenesis
osteoblast differentiation
negative regulation of cytokine production
blood vessel endothelial cell proliferation involved in sprouting angiogenesis
apoptotic process
response to stress
inflammatory response
cell adhesion
transmembrane receptor protein tyrosine kinase signaling pathway
intrinsic apoptotic signaling pathway in response to DNA damage
regulation of lamellipodium assembly
notochord formation
cell migration
negative regulation of angiogenesis
neural tube development
central nervous system neuron differentiation
cell differentiation
regulation of cell adhesion
keratinocyte differentiation
osteoclast differentiation
regulation of cell migration
positive regulation of cell migration
epithelial cell differentiation
negative regulation of chemokine production
mammary gland epithelial cell proliferation
regulation of cell adhesion mediated by integrin
post-anal tail morphogenesis
regulation of blood vessel endothelial cell migration
regulation of angiogenesis
cAMP metabolic process
viral entry into host cell
bone remodeling
ephrin receptor signaling pathway
axial mesoderm formation
animal organ development
blood vessel morphogenesis
notochord morphogenesis
cell motility
defense response to Gram-positive bacterium
notochord cell development
cell chemotaxis
branching involved in mammary gland duct morphogenesis
lens fiber cell morphogenesis
regulation of ERK1 and ERK2 cascade
response to growth factor
protein localization to plasma membrane
activation of GTPase activity
negative regulation of lymphangiogenesis
positive regulation of protein localization to plasma membrane
positive regulation of bicellular tight junction assembly
pericyte cell differentiation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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