Search

  • Contact Us
  • Quick Order

Proteintech

HO-1/HMOX1 Monoclonal Antibody (2D10A5)

93 References
View all (38) HO-1 antibodies

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Additional Information:
{{banner.description}}
{{$ctrl.isSkuNotesCollapsed ? 'View more' : 'View less'}}
HO-1/HMOX1 Monoclonal Antibody (2D10A5)

Product Details

66743-1-IG

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:6,000
View 79 publications 79 publications

Immunohistochemistry (IHC)

-
View 6 publications 6 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:500-1:2,000
-

Immunohistochemistry (PFA fixed) (IHC (PFA))

1:1,000
-

Immunocytochemistry (ICC/IF)

-
View 5 publications 5 publications

Immunoprecipitation (IP)

-
View 3 publications 3 publications
Product Specifications

Species Reactivity

Human, Mouse, Pig, Rabbit, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

2D10A5

Immunogen

HO-1/HMOX1 Fusion Protein Ag21296 (1-288 aa encoded by BC001491)
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

150 µg

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MERPQPDSM PQDLSEALKE ATKEVHTQAE NAEFMRNFQK GQVTRDGFKL VMASLYHIYV ALEEEIERNK ESPVFAPVYF PEELHRKAAL EQDLAFWYGP RWQEVIPYTP AMQHYVKRLH EVGRTEPELL VAHAYTRYLG DLSGGQVLKK IAQKALDLPS SGEGLAFFTF PNIASATKFK QLYRSRMNSL EMTPAVRQRV IEEAKTAFLL NIQLFEELQE LLTHDTKDQS PSRAPGLRQR ASNKVQDSAP VETPRGKPPL NTRSQAPLLR WVLTLSFLVA TVAVGLYAM (1-288 aa encoded by BC001491 )

Target Information

Heme oxygenase (HO) is a microsomal enzyme that catalyzes the oxidation of heme to the antioxidant molecules, biliverdin and carbon monoxide. HO consists of two homologous isozymes, an inducible HO-1 and a constitutively expressed HO-2. HO-1 is induced by a wide variety of stimuli including conditions of oxidative stress, inflammatory agents, transforming growth factor beta and heat shock. The increase in expression of HO-1 is thought to be a cellular defense mechanism against oxidative stress since elevated HO could eventually generate more bilirubin, an anti-oxidant.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: heat shock protein 32; heat shock protein, 32-kD; heme orygenase 1; heme oxygenase (decycling) 1; heme oxygenase (decyclizing) 1; Heme oxygenase 1; hemoxygenase; HMOX1; HO-1; HSP32; P32 protein; unnamed protein product

View more View less

Gene Aliases: bK286B10; D8Wsu38e; Hemox; Heox; HEOXG; Hmox; HMOX1; HMOX1D; HO; HO-1; HO1; HSP32

View more View less

UniProt ID: (Pig) P32394, (Human) P09601, (Rat) P06762, (Mouse) P14901

View more View less

Entrez Gene ID: (Pig) 445512, (Rabbit) 100008919, (Human) 3162, (Rat) 24451, (Mouse) 15368

View more View less

Function(s)
heme oxygenase (decyclizing) activity heme binding identical protein binding protein homodimerization activity metal ion binding structural molecule activity protein binding oxidoreductase activity enzyme binding phospholipase D activity signal transducer activity oxygenase
Process(es)
wound healing involved in inflammatory response heme oxidation cellular iron ion homeostasis apoptotic process response to oxidative stress erythrocyte homeostasis regulation of transcription from RNA polymerase II promoter in response to iron response to nicotine heme catabolic process heme metabolic process positive regulation of I-kappaB kinase/NF-kappaB signaling negative regulation by host of viral transcription positive regulation of smooth muscle cell proliferation negative regulation of smooth muscle cell proliferation iron ion homeostasis cellular response to arsenic-containing substance cellular response to cadmium ion negative regulation of extrinsic apoptotic signaling pathway via death domain receptors negative regulation of viral life cycle angiogenesis endothelial cell proliferation negative regulation of leukocyte migration regulation of transcription from RNA polymerase II promoter smooth muscle hyperplasia macroautophagy positive regulation of macroautophagy negative regulation of macroautophagy positive regulation of chemokine production low-density lipoprotein particle clearance cellular response to heat intracellular signal transduction response to hydrogen peroxide regulation of angiogenesis positive regulation of angiogenesis multicellular organismal iron ion homeostasis cellular response to cisplatin positive regulation of cell migration involved in sprouting angiogenesis negative regulation of ferroptosis negative regulation of cytokine production involved in inflammatory response positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis epithelial cell apoptotic process positive regulation of epithelial cell apoptotic process response to hypoxia phospholipid metabolic process small GTPase mediated signal transduction regulation of blood pressure cell death negative regulation of cell proliferation intrinsic apoptotic signaling pathway in response to DNA damage negative regulation of muscle cell apoptotic process cellular response to nutrient negative regulation of mast cell cytokine production negative regulation of mast cell degranulation negative regulation of DNA binding negative regulation of sequence-specific DNA binding transcription factor activity negative regulation of neuron apoptotic process regulation of transcription from RNA polymerase II promoter in response to oxidative stress response to estrogen regulation of sequence-specific DNA binding transcription factor activity protein homooligomerization cellular response to hypoxia oxidation-reduction process
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support