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Proteintech
DKK3 Monoclonal Antibody (4E6H6)
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Product Details
66758-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Pig,
Rat
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
4E6H6
Immunogen
DKK3 Fusion Protein Ag23615 (37-350 aa encoded by BC007660)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
150 µg
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: ALSYPQEEA TLNEMFREVE ELMEDTQHKL RSAVEEMEAE EAAAKASSEV NLANLPPSYH NETNTDTKVG NNTIHVHREI HKITNNQTGQ MVFSETVITS VGDEEGRRSH ECIIDEDCGP SMYCQFASFQ YTCQPCRGQR MLCTRDSECC GDQLCVWGHC TKMATRGSNG TICDNQRDCQ PGLCCAFQRG LLFPVCTPLP VEGELCHDPA SRLLDLITWE LEPDGALDRC PCASGLLCQP HSHSLVYVCK PTFVGSRDQD GEILLPREVP DEYEVGSFME EVRQELEDLE RSLTEEMALG EPAAAAAALL GGEEI (37-350 aa encoded by B C007660)
Target Information
DKK3, like DKK1, DKK2, and DKK4, possesses an N-terminal signal peptide and 2 conserved cysteine-rich domains, which are separated by a linker region and contain 10 cysteine residues each. The second cysteine region has a putative lipid-binding function that may facilitate WNT/DKK interactions at the plasma membrane. The linker region contains 50 to 55 amino acids in DKK1, DKK2, and DKK4, whereas in DKK3 it contains only 12 amino acids. All DKKs have several potential sites for cleavage by furin-type proteases. Northern blot analysis revealed wide expression of the DKK3 transcript, with highest expression in heart, brain, and spinal cord. In situ hybridization reveals highest expression in mouse brain, eye, and heart.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: cardiomyocyte regeneration-related lncRNA; Dickkopf; dickkopf 3; dickkopf 3 homolog; Dickkopf gene 3; dickkopf homolog 3; Dickkopf-3; Dickkopf-related protein 3; Dickkopf3; DKK 3; dkk-3; hDkk 3; hDkk-3; hhDkk3; mDkk-3; regulated in glioma; REIC/Dkk-3; RIG; RIG-like 5-6; RIG-like 7-1; unnamed protein product; Xenopus
Gene Aliases: AW061014; C87148; CRRL; DKK3; p29; REIC; RIG; UNQ258/PRO295
UniProt ID: (Human) Q9UBP4, (Mouse) Q9QUN9
Entrez Gene ID: (Human) 27122, (Pig) 664653, (Rat) 171548, (Mouse) 50781
anatomical structure morphogenesis
Wnt signaling pathway
regulation of transforming growth factor beta receptor signaling pathway
negative regulation of Wnt signaling pathway
adrenal gland development
negative regulation of aldosterone biosynthetic process
negative regulation of transcription, DNA-templated
negative regulation of canonical Wnt signaling pathway
negative regulation of anti-Mullerian hormone signaling pathway
negative regulation of cortisol biosynthetic process
multicellular organism development
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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