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Proteintech
FNTB Monoclonal Antibody (1F3B10)
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Product Details
66783-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1F3B10
Immunogen
FNTB Fusion Protein Ag27796 (1-356 aa encoded by BC020232)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein G
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MASPSSFTY YCPPSSSPVW SEPLYSLRPE HARERLQDDS VETVTSIEQA KVEEKIQEVF SSYKFNHLVP RLVLQREKHF HYLKRGLRQL TDAYECLDAS RPWLCYWILH SLELLDEPIP QIVATDVCQF LELCQSPEGG FGGGPGQYPH LAPTYAAVNA LCIIGTEEAY DIINREKLLQ YLYSLKQPDG SFLMHVGGEV DVRSAYCAAS VASLTNIITP DLFEGTAEWI ARCQNWEGGI GGVPGMEAHG GYTFCGLAAL VILKRERSLN LKSLLQWVTS RQMRFEGGFQ GRCNKLVDGC YSFWQAGLLP LLHRALHAQG DPALSMSHWM FHQQALQEYI LMCCQCPAGG LLDKPGK (1-356 aa encoded by BC020232)
Target Information
Eukaryotic cells contain 3 different types of prenyltransferases that attach either a farnesyl group (15 carbons) or a geranylgeranyl group (20 carbons) in thioether linkage to C-terminal cysteine residues in a variety of proteins. These posttranslational modifications provide a mechanism for membrane localization of proteins that lack a transmembrane domain. CAAX farnesyltransferase (FTase) attaches a farnesyl group from farnesyl pyrophosphate to cysteine residues at the fourth position from the C terminus of proteins that end in the CAAX box, where C is cysteine, A is usually but not always an aliphatic amino acid, and X is typically methionine or serine. This enzyme has the ability to farnesylate peptides as short as 4 residues in length that conform to the CAAX consensus sequence. The gene for the beta subunit of CAAX farnesyltransferase (FNTB) has been pinpointed to 14q23-q24 by Southern blot hybridization and PCR analyses of panels of human/Chinese hamster somatic cell hybrid lines and by fluorescence chromosomal in situ hybridization.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CAAX farnesyltransferase subunit beta; EC 2.5.1.58; epididymis secretory sperm binding protein; farnesyltransferase, CAAX box, beta; ft beta; FTase beta; FTase-beta; Protein farnesyltransferase subunit beta; Ras proteins prenyltransferase subunit beta; unnamed protein product
Gene Aliases: 2010013E13Rik; AA409500; FNTB; FPTB
UniProt ID: (Human) P49356, (Mouse) Q8K2I1
Entrez Gene ID: (Human) 2342, (Mouse) 110606
catalytic activity
prenyltransferase activity
protein farnesyltransferase activity
protein binding
zinc ion binding
protein prenyltransferase activity
acetyltransferase activator activity
transferase activity
enzyme binding
peptide binding
metal ion binding
farnesyltranstransferase activity
drug binding
isoprenoid binding
acyltransferase
lipid metabolic process
positive regulation of cell proliferation
protein farnesylation
positive regulation of cell cycle
regulation of microtubule-based movement
negative regulation of cell proliferation
response to inorganic substance
response to organic cyclic compound
response to cytokine
wound healing
regulation of cell proliferation
positive regulation of fibroblast proliferation
positive regulation of nitric-oxide synthase biosynthetic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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