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Proteintech
PABPC1/PABP Monoclonal Antibody (3D8B5)
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Product Details
66809-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
3D8B5
Immunogen
PABPC1,PABP Fusion Protein Ag27860
Conjugate
Form
Liquid
Concentration
1000 µg/mL
Amount
150 µg
Purification
Protein G
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Aliquoting is unnecessary for -20°C storage.
Target Information
The poly(A)-binding protein (PABP), which is found complexed to the 3-prime poly(A) tail of eukaryotic mRNA, is required for poly(A) shortening and translation initiation. In humans, the PABPs comprise a small nuclear isoform and a conserved gene family that displays at least 3 functional proteins: PABP1 (PABPC1), inducible PABP (iPABP, or PABPC4), and PABP3 (PABPC3). In addition, there are at least 4 pseudogenes, PABPCP1 to PABPCP4.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: PABP 1; PABP-1; poly(A) binding protein, cytoplasmic 2; poly(A)-binding protein 1; Polyadenylate-binding protein 1; unnamed protein product
Gene Aliases: PAB1; PABP; PABP1; PABPC1; PABPC2; PABPL1
UniProt ID: (Human) P11940, (Rat) Q9EPH8
Entrez Gene ID: (Human) 26986, (Rat) 171350
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
mRNA processing
RNA splicing
gene silencing by RNA
positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
mRNA splicing, via spliceosome
positive regulation of viral genome replication
mRNA stabilization
CRD-mediated mRNA stabilization
negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
positive regulation of cytoplasmic translation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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