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Proteintech
SMO Monoclonal Antibody (2A11A10)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
66851-2-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Dog,
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
2A11A10
Immunogen
SMO fusion protein Ag25861
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
150 µg
Purification
Protein G
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: RGAASSGNAT GPGPRSAGGS ARRSAAVTGP PPPLSHCGRA APCEPLRYNV CLGSVLPYGA TSTLLAGDSD SQEEAHGKLV LWSGLRNAPR CWAVIQPLLC AVYMPKCEND RVELPSRTLC QATRGPCAIV ERERGWPDFL RCTPDRFPEG CTNEVQNIKF NSSGQCEVPL VRTDNPKSWY EDVEGCGIQC QNPLFTEAEH QDMHSY
Target Information
Smoothened drosophila homolog (SMOH) is a serpentine protein belonging to the G-protein coupled receptor Fz/Smo family with 787 aa, seven transmembrane G protein-coupled receptors with 4 glycosylation sites and a putative extracellular amino terminus. Smoothened activated by b-Arrestin 2 and GRK2 acts as a receptor for Shh, the Sonic hedgehog gene product, and is a positive regulator of hedgehog signaling pathway along with the smoothened inhibitor patched protein (PTCH) and regulates vertebrate developmental processes, cellular proliferation and differentiation by activating transcription factor Gli. Smoothened mutants are known to cause sporadic basal cell carcinoma of the skin. It is known to express widely in heart and brain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: candidate receptor for sonic hedgehog; frizzled family member 11; HGNC:11119; protein Gx; Protein SMOH; seven transmembrane helix receptor; smoothened homolog; smoothened, frizzled family receptor; smoothened, seven transmembrane spanning receptor
Gene Aliases: CRJS; FZD11; Gx; PHLS; SMOH
UniProt ID: (Human) Q99835
Entrez Gene ID: (Human) 6608, (Dog) 482262
heart looping
determination of left/right asymmetry in lateral mesoderm
cell surface receptor signaling pathway
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
smoothened signaling pathway
ventral midline determination
pattern specification process
central nervous system development
midgut development
tissue development
positive regulation of gene expression
spinal cord dorsal/ventral patterning
positive regulation of cell migration
positive regulation of multicellular organism growth
positive regulation of smoothened signaling pathway
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of organ growth
smooth muscle tissue development
forebrain morphogenesis
contact inhibition
somite development
cellular response to cholesterol
commissural neuron axon guidance
mesenchymal to epithelial transition involved in metanephric renal vesicle formation
positive regulation of branching involved in ureteric bud morphogenesis
regulation of heart morphogenesis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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