Search
Proteintech
LGMN Monoclonal Antibody (1F2B12)
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Product Details
67017-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1F2B12
Immunogen
LGMN Fusion Protein Ag7218
Conjugate
Form
Liquid
Concentration
960 µg/mL
Amount
144 µg
Purification
Protein G
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Aliquoting is unnecessary for -20°C storage.
Target Information
This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: AEP; Asparaginyl endopeptidase; cysteine protease 1; Legumain; LGMN; Protease, cysteine 1; protease, cysteine, 1 (legumain); PRSC1EC 3.4.22.34; unnamed protein product
Gene Aliases: AEP; LGMN; LGMN1; PRSC1
UniProt ID: (Human) Q99538
Entrez Gene ID: (Human) 5641
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
renal system process
proteolysis
vacuolar protein processing
memory
positive regulation of cell proliferation
associative learning
response to acidic pH
negative regulation of gene expression
antigen processing and presentation of exogenous peptide antigen via MHC class II
receptor catabolic process
cellular response to hepatocyte growth factor stimulus
negative regulation of multicellular organism growth
vitamin D metabolic process
antigen processing and presentation of exogenous peptide antigen via MHC class I
negative regulation of neuron apoptotic process
positive regulation of mitotic cell cycle
proteolysis involved in cellular protein catabolic process
protein maturation
cellular response to calcium ion
positive regulation of monocyte chemotaxis
dendritic spine organization
positive regulation of long-term synaptic potentiation
negative regulation of ERBB signaling pathway
cellular response to beta-amyloid
positive regulation of endothelial cell chemotaxis
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support