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Proteintech
GUK1 Monoclonal Antibody (2H5E1)
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Product Details
67047-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
2H5E1
Immunogen
GUK1 Fusion Protein Ag28805
Conjugate
Form
Liquid
Concentration
1000 µg/mL
Amount
150 µg
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Aliquoting is unnecessary for -20°C storage.
Target Information
Guanylate kinase (GK) catalyzes the ATP-dependent phosphorylation of GMP into GDP. It is essential for recycling GMP and indirectly, cGMP. In prokaryotes (such as Escherichia coli), lower eukaryotes (such as yeast) and in vertebrates, GK is a highly conserved monomeric protein of about 200 amino acids. GK has been shown to be structurally similar to protein A57R (or SalG2R) from various strains of Vaccinia virus. Proteins containing one or more copies of the DHR domain, an SH3 domain as well as a C-terminal GK-like domain, are collectively termed MAGUKs (membrane-associated guanylate kinase homologs) and include Drosophila lethal(1)discs large-1 tumor suppressor protein (gene dlg1); mammalian tight junction protein Zo-1; a family of mammalian synaptic proteins that seem to interact with the cytoplasmic tail of NMDA receptor subunits (SAP90/PSD-95, CHAPSYN-110/PSD-93, SAP97/DLG1 and SAP102); vertebrate 55 kD erythrocyte membrane protein (p55); C. elegans protein lin-2; rat protein CASK; and human proteins DLG2 and DLG3. There is an ATP-binding site (P-loop) in the N-terminal section of GK, which is not conserved in the GK-like domain of the above proteins. However these proteins retain the residues known, in GK, to be involved in the binding of MP.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ATP:GMP phosphotransferase; ATP:GMP-phosphotransferase; GMP kinase; Guanylate kinase; Guanylate kinase 1; GUK1; RP11-520H14.2; unnamed protein product
Gene Aliases: AA409738; AL033299; AL033300; AV026611; GMK; GMPK; Guk-1; GUK1; MTDPS21
UniProt ID: (Human) Q16774, (Mouse) Q64520
Entrez Gene ID: (Human) 2987, (Mouse) 14923, (Rat) 303179
purine nucleotide metabolic process
dGDP biosynthetic process
xenobiotic metabolic process
nucleobase-containing small molecule interconversion
GDP-mannose metabolic process
glycoprotein transport
GMP metabolic process
dGMP metabolic process
dATP metabolic process
GDP biosynthetic process
phosphorylation
ATP metabolic process
nucleotide phosphorylation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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