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Proteintech
VAMP4 Monoclonal Antibody (3A6F2)
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Product Details
67219-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Pig,
Rat
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
3A6F2
Immunogen
VAMP4 Fusion Protein Ag27854
Conjugate
Form
Liquid
Concentration
1000 µg/mL
Amount
150 µg
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Aliquoting is unnecessary for -20°C storage.
Target Information
The vesicle associated membrane proteins (VAMP) or synaptobrevins are calcium binding proteins specific to eukaryotes. VAMPs, along with synaptosomal associated protein of 25 kDa (SNAP-25) and syntaxin, form the core complex of soluble NSF attachment protein receptor (SNARE) proteins that interact with the soluble proteins N-ethylmaleimide-sensitive factor (NSF) and alpha-SNAP. These membrane associated proteins play a key role in the regulation of vesicle membrane fusion with the plasma membrane. The Clostridium tetani neurotoxin is a metalloprotease with specificity for VAMP. In Alzheimer's disease, VAMP levels of all isoforms appear to be significantly lowered.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: unnamed protein product; vamp; VAMP family member; VAMP-4; VAMP4; VAMP4/TAF3 fusion; vesicle associated membrane protein 4; Vesicle-associated membrane protein 4
Gene Aliases: D1Ertd147e; VAMP-4; VAMP24; VAMP4
UniProt ID: (Human) O75379, (Mouse) O70480
Entrez Gene ID: (Pig) 100512732, (Human) 8674, (Mouse) 53330, (Rat) 364033
synaptic vesicle to endosome fusion
vesicle-mediated transport
endocytic recycling
SNARE complex assembly
regulation of Golgi to plasma membrane protein transport
Golgi to plasma membrane protein transport
cellular response to interferon-gamma
Golgi ribbon formation
vesicle-mediated transport to the plasma membrane
neurotransmitter receptor transport, endosome to postsynaptic membrane
vesicle-mediated transport in synapse
regulation of synaptic vesicle endocytosis
microtubule cytoskeleton organization
exocytosis
vesicle fusion
toxin transport
ER to Golgi vesicle-mediated transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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