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Proteintech
Collagen Type I Monoclonal Antibody (1E9A7)
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Product Details
67288-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Pig
Published species
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1E9A7
Immunogen
Peptide
Conjugate
Form
Liquid
Concentration
500 µg/mL
Amount
75 µg
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Aliquoting is unnecessary for -20°C storage.
Target Information
Collagen I is a Type I collagen with a triple helix structure comprised of two alpha-1 chains and one alpha-2 chain. Collagen I is a member of group I collagen (fibril-forming collagen) found in most connective tissues, and is abundant in bone, cornea, dermis and tendon. Mutations in the COL1A2 gene encoding the alpha-2 chain are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIB, recessive Ehlers-Danlos syndrome Classical type, idiopathic osteoporosis, and atypical Marfan syndrome. Symptoms associated with mutations in the COL1A2 gene which codes for the alpha-2 chain, however, tend to be less severe than mutations in the COL1A1 gene, reflecting the different role of alpha-2 chains in matrix integrity. Reciprocal translocations between chromosomes 17 and 22, where Collagen Type 1 genes and the gene for platelet derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: alpha 1 (I) chain propeptide; alpha 2 type I procollagen; alpha 2(I) procollagen; alpha 2(I)-collagen; alpha-1 collagen type 1; alpha-1 collagen type I; Alpha-1 type I collagen; Alpha-2 type I collagen; alpha1 chain of type I collagen; alpha1(I) procollagen; alpha2 chain of type I collagen; COL1; COL1A1; COL1A1; matrix protein; collagen 1 pro-alpha-2 chain; collagen alpha 1 chain type I; Collagen alpha-1(I) chain; collagen alpha-1(I) chain preproprotein; Collagen alpha-2(I) chain; collagen Col1-ColIII-1; collagen Col1-ColIII-2; collagen I, alpha-2 polypeptide; collagen of skin, tendon and bone, alpha-1 chain; collagen of skin, tendon and bone, alpha-2 chain; collagen type I alpha 1; collagen, type I, alpha 1; collagen, type I, alpha 2; epididymis secretory sperm binding protein; pre-pro-alpha-2 type I collagen; pro-alpha-1 collagen type 1; Type I Collagen; type I proalpha 1; type I procollagen; type I procollagen alpha 1 chain; unnamed protein product
Gene Aliases: CAFYD; COL1A1; COL1A2; EDSARTH1; EDSARTH2; EDSC; EDSCV; OI1; OI2; OI3; OI4
UniProt ID: (Human) P02452, (Human) P08123
Entrez Gene ID: (Pig) 100738123, (Human) 1277, (Human) 1278, (Pig) 100626716
protease binding
extracellular matrix structural constituent
protein binding
extracellular matrix structural constituent conferring tensile strength
identical protein binding
metal ion binding
platelet-derived growth factor binding
protein binding, bridging
SMAD binding
extracellular matrix structural protein
skeletal system development
ossification
blood vessel development
osteoblast differentiation
intramembranous ossification
endochondral ossification
response to nutrient
visual perception
sensory perception of sound
response to xenobiotic stimulus
response to mechanical stimulus
positive regulation of epithelial to mesenchymal transition
negative regulation of cell-substrate adhesion
protein transport
collagen fibril organization
positive regulation of cell migration
response to nutrient levels
response to estradiol
response to insulin
collagen biosynthetic process
protein localization to nucleus
tooth mineralization
collagen-activated tyrosine kinase receptor signaling pathway
response to hydrogen peroxide
response to peptide hormone
skin development
skin morphogenesis
cellular response to fibroblast growth factor stimulus
positive regulation of transcription, DNA-templated
animal organ development
response to steroid hormone
skeletal system morphogenesis
embryonic skeletal system development
system development
response to cAMP
response to hyperoxia
face morphogenesis
bone trabecula formation
cartilage development involved in endochondral bone morphogenesis
cellular response to amino acid stimulus
cellular response to mechanical stimulus
cellular response to retinoic acid
cellular response to vitamin E
cellular response to glucose stimulus
cellular response to tumor necrosis factor
cellular response to epidermal growth factor stimulus
cellular response to transforming growth factor beta stimulus
positive regulation of canonical Wnt signaling pathway
response to fluoride
cellular response to fluoride
transforming growth factor beta receptor signaling pathway
Rho protein signal transduction
regulation of blood pressure
bone mineralization
collagen metabolic process
odontogenesis
protein heterotrimerization
extracellular matrix assembly
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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