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Proteintech
PURA Monoclonal Antibody (1C6G4)
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Product Details
67305-1-IG
Product Specifications
Species Reactivity
Human,
Mouse,
Pig,
Rat
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
1C6G4
Immunogen
PURA Fusion Protein Ag12164
Conjugate
Form
Liquid
Concentration
1000 µg/mL
Amount
150 µg
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Aliquoting is unnecessary for -20°C storage.
Target Information
This gene product is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans. Thus, it is implicated in the control of both DNA replication and transcription. Deletion of this gene has been associated with myelodysplastic syndrome and acute myelogenous leukemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Pur alpha; pura {ECO:0000250|UniProtKB:P42669}; purine rich element binding protein A; purine-rich element binding protein A; Purine-rich single-stranded DNA-binding protein alpha; purine-rich single-stranded DNA-binding protein alpha {ECO:0000250|UniProtKB:P42669}; Transcriptional activator protein Pur-alpha; transcriptional activator protein Pur-alpha {ECO:0000250|UniProtKB:P42669}
Gene Aliases: CAGER-1; MRD31; NEDRIHF; PUR-ALPHA; PUR1; PURA; PURALPHA; ssCRE-BP
UniProt ID: (Human) Q00577, (Mouse) P42669
Entrez Gene ID: (Pig) 100625926, (Human) 5813, (Mouse) 19290, (Rat) 307498
translation repressor activity, nucleic acid binding
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
double-stranded DNA binding
double-stranded telomeric DNA binding
single-stranded DNA binding
transcription factor activity, sequence-specific DNA binding
RNA binding
protein binding
purine-rich negative regulatory element binding
SMAD binding
DNA-binding transcription factor binding
transcription regulator inhibitor activity
transcription factor binding
poly(A) RNA binding
DNA-binding transcription factor
negative regulation of transcription from RNA polymerase II promoter
DNA replication initiation
regulation of transcription from RNA polymerase II promoter
nervous system development
cell proliferation
positive regulation of cell proliferation
negative regulation of translation
negative regulation of transcription, DNA-templated
lymphocyte proliferation
epithelial cell proliferation
dendritic transport of messenger ribonucleoprotein complex
DNA unwinding involved in DNA replication
transcription, DNA-templated
regulation of transcription, DNA-templated
apoptotic process
mitotic cell cycle checkpoint
cell differentiation
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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