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TLR8 Monoclonal Antibody (3B6A4)
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Product Details
67317-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
3B6A4
Immunogen
TLR8 Fusion Protein Ag16566
Conjugate
Form
Liquid
Concentration
500 µg/mL
Amount
75 µg
Purification
Protein G
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Aliquoting is unnecessary for -20°C storage.
Target Information
The TLR8 protein is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. The TLR8 gene is predominantly expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD antigen 288; CD288; TLR8; TLR8 isoform 1; Toll-like receptor 8; unnamed protein product
Gene Aliases: CD288; hTLR8; IMD98; TLR-8; TLR8; UNQ249/PRO286
UniProt ID: (Human) Q9NR97
Entrez Gene ID: (Human) 51311
toll-like receptor signaling pathway
immune system process
inflammatory response
immune response
signal transduction
I-kappaB kinase/NF-kappaB signaling
response to virus
immunoglobulin mediated immune response
negative regulation of interleukin-12 production
positive regulation of interferon-alpha production
positive regulation of interferon-beta production
positive regulation of interferon-gamma production
positive regulation of interleukin-1 beta production
positive regulation of interleukin-6 production
positive regulation of interleukin-8 production
toll-like receptor 8 signaling pathway
positive regulation of I-kappaB kinase/NF-kappaB signaling
innate immune response
positive regulation of innate immune response
defense response to virus
cellular response to mechanical stimulus
defense response to other organism
endolysosomal toll-like receptor signaling pathway
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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