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Proteintech
KL Monoclonal Antibody (4D1G11)
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Product Details
67331-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
4D1G11
Immunogen
KL Fusion Protein Ag27838
Conjugate
Form
Liquid
Concentration
1000 µg/mL
Amount
150 µg
Purification
Protein G
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Aliquoting is unnecessary for -20°C storage.
Target Information
KLOTHO is the systemic anti-aging hormone within the glycosidase1 superfamily. It encodes a type I membrane protein that is abundant in the kidney and brain. In mice, a deficiency in KLOTHO expression leads to various systemic phenotypes resembling human aging such as arteriosclerosis, osteoporosis, and skin atrophy together with growth retardation, short life-span and infertility. Transgenic mice overexpressing KLOTHO have an extended life span by inhibiting insulin/IGF1 signaling. KLOTHO is involved in the regulation of calcium/phosphorus homeostasis by inhibiting the synthesis of active vitamin D and identified as a potential tumor suppressor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: alpha-klotho; HFTC3; Klotho; secreted form of Klotho protein; unnamed protein product
Gene Aliases: alpha-kl; HFTC3; KL; KLA
UniProt ID: (Human) Q9UEF7, (Rat) Q9Z2Y9, (Mouse) O35082
Entrez Gene ID: (Human) 9365, (Rat) 83504, (Mouse) 16591
hydrolase activity, hydrolyzing O-glycosyl compounds
beta-glucuronidase activity
fibroblast growth factor receptor binding
hormone activity
vitamin D binding
beta-glucosidase activity
hydrolase activity
hydrolase activity, acting on glycosyl bonds
fibroblast growth factor binding
signal transducer activity
protein binding
glycosidase
negative regulation of systemic arterial blood pressure
carbohydrate metabolic process
energy reserve metabolic process
determination of adult lifespan
fibroblast growth factor receptor signaling pathway
response to activity
positive regulation of bone mineralization
response to vitamin D
norepinephrine biosynthetic process
calcium ion homeostasis
response to fibroblast growth factor
positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
response to angiotensin
acute inflammatory response
aging
insulin receptor signaling pathway
metabolic process
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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