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Proteintech
PFN1 Monoclonal Antibody (3A12E8)
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Product Details
67390-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
3A12E8
Immunogen
PFN1 Fusion Protein Ag29206
Conjugate
Form
Liquid
Concentration
1000 µg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Aliquoting is unnecessary for -20°C storage.
Target Information
Profilin is an ubiquitous small (12-15 kDa) phosphoinositides and poly-L-proline binding protein that plays a role in both signal transduction pathways and actin filament dynamics. There are two mammalian profilins with similar biochemical properties but different expression patterns. Profilin I appears to be highly expressed in most tissues except for skeletal muscle. Profilin II is predominantly expressed in brain and at lower levels in skeletal muscle, uterus and kidney. Profilin is a mainly cytosolic protein with higher concentrations in dynamic membrane areas like the leading edge and ruffling membranes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: actin binding protein; Epididymis tissue protein Li 184a; PFN1; profilin; Profilin I; Profilin-1; unnamed protein product
Gene Aliases: ALS18; Pfn; PFN1
UniProt ID: (Human) P07737, (Rat) P62963, (Mouse) P62962
Entrez Gene ID: (Human) 5216, (Rat) 64303, (Mouse) 18643
adenyl-nucleotide exchange factor activity
phosphotyrosine binding
RNA binding
actin binding
actin monomer binding
protein binding
phosphatidylinositol-4,5-bisphosphate binding
small GTPase binding
cadherin binding
proline-rich region binding
receptor binding
Rho GTPase binding
poly(A) RNA binding
actin or actin-binding cytoskeletal protein
cytoskeletal protein
non-motor actin binding protein
neural tube closure
regulation of transcription from RNA polymerase II promoter
positive regulation of epithelial cell migration
actin cytoskeleton organization
regulation of actin filament polymerization
positive regulation of actin filament polymerization
negative regulation of actin filament bundle assembly
positive regulation of actin filament bundle assembly
modulation of synaptic transmission
protein stabilization
negative regulation of stress fiber assembly
synapse maturation
modification of postsynaptic actin cytoskeleton
regulation of actin filament organization
positive regulation of ruffle assembly
actin polymerization or depolymerization
response to organic substance
negative regulation of actin filament polymerization
positive regulation of ATPase activity
positive regulation of transcription from RNA polymerase II promoter
positive regulation of viral transcription
positive regulation of DNA metabolic process
positive regulation of stress fiber assembly
cellular response to growth factor stimulus
regulation of actin polymerization or depolymerization
sequestering of actin monomers
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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