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Proteintech
TRIM72 Monoclonal Antibody (5F2C11)
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Product Details
67403-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Pig
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
5F2C11
Immunogen
Recombinant protein
Conjugate
Form
Liquid
Purification
Protein A
Storage buffer
PBS with 50% glycerol
Contains
0.1% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: MRKEKSVAVL EHQLVEVEET VRQFRGAVGE QLGKMRVFLA ALEGSLDREA ERVRGEAGVA LRRELGSLNS YLEQLRQMEK VLEEVADKPQ TEFLMKYCLV TSRLQKILAE SPPPARLDIQ LPIIS
Target Information
Muscle-specific protein that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites. Specifically binds phosphatidylserine. Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site. This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation. Probably acts upstream of the Ca(2+)-dependent membrane resealing process. Required for transport of DYSF to sites of cell injury during repair patch formation. Regulates membrane budding and exocytosis. May be involved in the regulation of the mobility of KCNB1-containing endocytic vesicles.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Mg53; mitsugumin 53; Mitsugumin-53; trim72; tripartite motif containing 72, E3 ubiquitin protein ligase; Tripartite motif-containing protein 72; unnamed protein product
Gene Aliases: BC067209; MG53; TRIM72
UniProt ID: (Human) Q6ZMU5, (Mouse) Q1XH17
Entrez Gene ID: (Human) 493829, (Pig) 100511188, (Mouse) 434246
plasma membrane repair
muscle system process
exocytosis
muscle organ development
negative regulation of myotube differentiation
proteasome-mediated ubiquitin-dependent protein catabolic process
negative regulation of insulin-like growth factor receptor signaling pathway
innate immune response
negative regulation of insulin receptor signaling pathway
protein homooligomerization
transport
membrane budding
protein ubiquitination
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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