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Proteintech

GATA2 Monoclonal Antibody (2B5A1)

View all (18) GATA2 antibodies

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Product Details

67722-1-IG

Applications
Tested Dilution
Publications

Western Blot (WB)

1:4,000
-

Immunocytochemistry (ICC/IF)

1:400
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

2B5A1

Immunogen

GATA2 Fusion Protein Ag1557

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

2300 µg/mL

Amount

345 µg

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

Product Specific Information

Aliquoting is unnecessary for -20°C storage.

Target Information

GATA2 (GATA binding protein 2) belongs to the GATA family of transcription factors. GATA proteins play a very important role in signaling pathways controlling proliferation and differentiation of erythroid progenitor cells. There are 6 transcription factors in the GATA family: GATA1 to GATA6. GATA2 is a transcriptional activator regulating endothelin-1 gene expression in endothelial cells. It also appears to be involved in differentiation of other tissue types (uro-genital and nervous) during embryogenesis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Endothelial transcription factor GATA-2; FLJ45948; GATA-binding protein 2; MGC2306; unnamed protein product

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Gene Aliases: DCML; Gata-2; GATA2; IMD21; MONOMAC; NFE1B

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UniProt ID: (Human) P23769, (Mouse) O09100

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Entrez Gene ID: (Human) 2624, (Mouse) 14461

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Function(s)
RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcription cofactor binding transcription coactivator binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding protein binding zinc ion binding sequence-specific DNA binding metal ion binding RNA polymerase II sequence-specific DNA binding transcription factor binding C2H2 zinc finger domain binding sequence-specific double-stranded DNA binding RNA polymerase II distal enhancer sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding enhancer sequence-specific DNA binding transcription factor binding DNA-binding transcription factor
Process(es)
negative regulation of transcription from RNA polymerase II promoter angiogenesis urogenital system development cell fate determination neuron migration embryonic placenta development glandular epithelial cell differentiation glandular epithelial cell maturation hematopoietic progenitor cell differentiation regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter phagocytosis positive regulation of cytosolic calcium ion concentration neuroblast proliferation negative regulation of neuroblast proliferation anatomical structure morphogenesis positive regulation of gene expression negative regulation of gene expression regulation of primitive erythrocyte differentiation ventral spinal cord interneuron differentiation cell differentiation in hindbrain commitment of neuronal cell to specific neuron type in forebrain central nervous system neuron differentiation central nervous system neuron development pituitary gland development myeloid cell differentiation cell differentiation neuron differentiation response to lipid somatic stem cell population maintenance eosinophil fate commitment inner ear morphogenesis neuron maturation positive regulation of mast cell degranulation positive regulation of blood vessel endothelial cell migration cell fate commitment fat cell differentiation negative regulation of myeloid cell differentiation positive regulation of erythrocyte differentiation negative regulation of macrophage differentiation positive regulation of megakaryocyte differentiation positive regulation of neuron differentiation negative regulation of Notch signaling pathway positive regulation of angiogenesis positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter neuron fate commitment system development homeostasis of number of cells within a tissue positive regulation of phagocytosis regulation of developmental process brown fat cell differentiation positive regulation of phagocytosis, engulfment thyroid-stimulating hormone-secreting cell differentiation definitive hemopoiesis semicircular canal development vascular wound healing neuroendocrine cell differentiation neural precursor cell proliferation hematopoietic stem cell homeostasis positive regulation of cell migration involved in sprouting angiogenesis cochlea development GABAergic neuron differentiation negative regulation of hematopoietic progenitor cell differentiation positive regulation of pri-miRNA transcription from RNA polymerase II promoter negative regulation of brown fat cell differentiation positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis negative regulation of neural precursor cell proliferation negative regulation of endothelial cell apoptotic process regulation of forebrain neuron differentiation transcription, DNA-templated hemopoiesis regulation of histone acetylation mast cell degranulation negative regulation of fat cell differentiation cell maturation negative regulation of fat cell proliferation
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