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Proteintech
KBTBD2 Monoclonal Antibody (2A9F3)
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Product Details
67895-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
2A9F3
Immunogen
KBTBD2 Fusion Protein Ag4933
Conjugate
Form
Liquid
Concentration
1000 µg/mL
Amount
150 µg
Purification
Protein G
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Aliquoting is unnecessary for -20°C storage.
Target Information
The KBTBD2 gene encodes the Kelch repeat and BTB (POZ) domain-containing protein 2, which is involved in various cellular processes, including protein ubiquitination and metabolic regulation. The KBTBD2 protein functions as a substrate adaptor for the Cullin-RING E3 ubiquitin ligase complex, facilitating the ubiquitination and subsequent proteasomal degradation of specific substrate proteins. This activity is crucial for maintaining cellular protein homeostasis and regulating metabolic pathways. KBTBD2 has been implicated in glucose metabolism and insulin signaling, where it plays a role in modulating the degradation of key regulatory proteins. Alterations in KBTBD2 function or expression are associated with metabolic disorders, such as obesity and type 2 diabetes. Additionally, KBTBD2's involvement in ubiquitin-mediated proteolysis underscores its significance in controlling various cellular responses and adaptations, making it a potential target for therapeutic interventions in metabolic diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BTB and kelch domain containing 1; BTB and kelch domain-containing protein 1; kelch repeat and BTB (POZ) domain containing 2; Kelch repeat and BTB domain-containing protein 2; unnamed protein product
Gene Aliases: BC022962; BKLHD1; CGI-73; KBTBD2; KIAA1489; mKIAA1489
UniProt ID: (Human) Q8IY47, (Mouse) G3X9X1
Entrez Gene ID: (Human) 25948, (Mouse) 210973, (Rat) 312372
glucose metabolic process
lipid metabolic process
gene expression
protein ubiquitination
response to insulin
cellular response to insulin stimulus
proteasome-mediated ubiquitin-dependent protein catabolic process
protein kinase B signaling
protein K48-linked ubiquitination
regulation of cellular response to insulin stimulus
biological_process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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