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Proteintech
AlaRS Monoclonal Antibody (1C8H3)
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Product Details
67909-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1C8H3
Immunogen
AARS Fusion Protein Ag11151
Conjugate
Form
Liquid
Concentration
1000 µg/mL
Purification
Protein G
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Aliquoting is unnecessary for -20°C storage.
Target Information
The human alanyl-tRNA synthetase (AARS) belongs to a family of tRNA synthases, of the class II enzymes. Class II tRNA synthases evolved early in evolution and are highly conserved. This is reflected by the fact that 498 of the 968-residue polypeptide human AARS shares 41% identity witht the E. coli protein. tRNA synthases are the enzymes that interpret the RNA code and attach specific aminoacids to the tRNAs that contain the cognate trinucleotide anticodons. They consist of a catalytic domain which interacts with the amino acid acceptor-T psi C helix of the tRNA, and a second domain which interacts with the rest of the tRNA structure.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: alanine tRNA ligase 1, cytoplasmic; Alanine--tRNA ligase, cytoplasmic; alanine--tRNA ligase, cytoplasmic {ECO:0000255|HAMAP-Rule:MF_03133}; Alanyl-tRNA synthetase; alanyl-tRNA synthetase {ECO:0000255|HAMAP-Rule:MF_03133}; alanyl-tRNA synthetase, cytoplasmic; AlaRS; alaRS {ECO:0000255|HAMAP-Rule:MF_03133}; Protein lactyltransferase AARS1; Protein sticky; Renal carcinoma antigen NY-REN-42; Sti; unnamed protein product
Gene Aliases: AARS; AARS1; AI316495; C76919; CMT2N; DEE29; EIEE29; HDLS2; sti; TTD8
UniProt ID: (Human) P49588, (Mouse) Q8BGQ7, (Rat) P50475
Entrez Gene ID: (Human) 16, (Mouse) 234734, (Rat) 292023
tRNA binding
nucleotide binding
aminoacyl-tRNA editing activity
Ser-tRNA(Ala) hydrolase activity
nucleic acid binding
RNA binding
aminoacyl-tRNA ligase activity
alanine-tRNA ligase activity
ATP binding
zinc ion binding
amino acid binding
ligase activity
metal ion binding
peptide lactyltransferase (ATP-dependent) activity
protein binding
ligase activity, forming aminoacyl-tRNA and related compounds
aminoacyl-tRNA synthetase
tRNA modification
translation
tRNA aminoacylation for protein translation
alanyl-tRNA aminoacylation
tRNA processing
cerebellar Purkinje cell layer development
DNA damage response, signal transduction by p53 class mediator
hippo signaling
positive regulation of hippo signaling
tRNA aminoacylation
negative regulation of neuron apoptotic process
neuromuscular process controlling balance
neuromuscular process
neuron apoptotic process
aminoacyl-tRNA metabolism involved in translational fidelity
regulation of cytoplasmic translational fidelity
negative regulation of signal transduction by p53 class mediator
hair follicle development
regulation of translational fidelity
protein folding
endoplasmic reticulum unfolded protein response
cellular response to unfolded protein
response to amino acid
skin development
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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