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Proteintech
HAT1 Monoclonal Antibody (1A11F6)
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FIGURE: 1 / 1
HAT1 Antibody (67971-1-IG150UL) in WB
Various lysates (LNCaP, HeLa, HEK-293, HepG2, Jurkat, K-562, HSC-T6, NIH/3T3, 4T1) were subjected to SDS PAGE followed by western blot with (Product # 67971-1-IG150UL) (HAT1 antibody) at dilution of 1:20,000 incubated at room temperature for 1.5 hours.
Product Details
67971-1-IG150UL
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1A11F6
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
150 µg
Purification
Protein G
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Target Information
The protein encoded by this gene is a type B histone acetyltransferase (HAT) that is involved in the rapid acetylation of newly synthesized cytoplasmic histones, which are in turn imported into the nucleus for de novo deposition onto nascent DNA chains. Histone acetylation, particularly of histone H4, plays an important role in replication-dependent chromatin assembly. Specifically, this HAT can acetylate soluble but not nucleosomal histone H4 at lysines 5 and 12, and to a lesser degree, histone H2A at lysine 5. Alternatively spliced transcript variants have been identified for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: hat1; histidine aminotransferase 1; Histone acetyltransferase 1; Histone acetyltransferase type B catalytic subunit; histone aminotransferase 1; Histone methacryltransferase HAT1
Gene Aliases: 2410071B14Rik; AA536933; Hat-1; HAT1; KAT1
UniProt ID: (Human) O14929, (Mouse) Q8BY71, (Rat) Q5M939
Entrez Gene ID: (Human) 8520, (Mouse) 107435, (Rat) 296501
histone acetyltransferase activity
protein binding
H4 histone acetyltransferase activity
transferase activity
transferase activity, transferring acyl groups
histone binding
histone acetyltransferase activity (H4-K12 specific)
peptide-lysine-N-acetyltransferase activity
molecular_function
histone modifying enzyme
chromatin organization
nucleosome assembly
internal protein amino acid acetylation
telomeric heterochromatin assembly
chromosome organization
DNA replication-dependent nucleosome assembly
DNA replication-independent nucleosome assembly
chromatin silencing at telomere
chromatin modification
histone acetylation
histone H4 acetylation
response to nutrient
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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