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Proteintech
RAD23B Monoclonal Antibody (2E6G9)
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Product Details
67988-1-IG150UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Pig,
Rat
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
2E6G9
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
150 µg
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Target Information
The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in the nucleotide excision repair (NER). This protein was found to be a component of the protein complex that specifically complements the NER defect of xeroderma pigmentosum group C (XP-c) cell extracts in vitro. This protein was also shown to interact with, and elevate the nucleotide excision activity of 3-methyladenine-DNA glycosylase (MPG), which suggested a role in DNA damage recognition in base excision repair. This protein contains an N-terminal ubiquitin-like domain, which was reported to interact with 26S proteasome, and thus this protein may be involved in the ubiquitin mediated proteolytic pathway in cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: HR23B; Lysine-specific demethylase RAD23B; p58; RAD23, yeast homolog of, B; RAD23b homolog; RAD23B; alternatively spliced; unnamed protein product; UV excision repair protein RAD23 homolog B; XP-C repair complementing complex 58 kDa; XP-C repair complementing protein; XP-C repair-complementing complex 58 kDa protein
Gene Aliases: 0610007D13Rik; AV001138; HHR23B; HR23B; Mhr23b; P58; RAD23B
UniProt ID: (Human) P54727, (Mouse) P54728, (Rat) Q4KMA2
Entrez Gene ID: (Human) 5887, (Pig) 100153668, (Mouse) 19359, (Rat) 298012
transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
damaged DNA binding
single-stranded DNA binding
protein binding
polyubiquitin binding
ubiquitin binding
RNA polymerase II sequence-specific DNA binding transcription factor binding
proteasome binding
DNA damage sensor activity
molecular_function
damaged DNA-binding protein
DNA repair
nucleotide-excision repair
cellular response to DNA damage stimulus
spermatogenesis
regulation of proteasomal ubiquitin-dependent protein catabolic process
proteasome-mediated ubiquitin-dependent protein catabolic process
embryonic organ development
cellular response to interleukin-7
nucleotide-excision repair, DNA damage recognition
biological_process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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