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Proteintech
DCLK1 Monoclonal Antibody (3C12C1)
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Product Details
68234-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Pig,
Rabbit,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
3C12C1
Immunogen
Recombinant protein
Conjugate
Form
Liquid
Purification
Protein G
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: LITMMLLVDV DQRFSAVQVL EHPWVNDDGL PENEHQLSVA GKIKKHFNTG PKPNSTAAGV SVIALDHGFT IKRSGSLDYY QQPGMYWIRP PLLIRRGRFS DEDATRM
Target Information
DCAMKL1 (DCLK1) serine/threonine kinase or DCLK1 or doublecortin-like kinase 1 contains two N-terminal doublecortin domains (which bind microtubules and regulate microtubule polymerization), a C-terminal serine/threonine protein kinase domain (which shows substantial homology to Ca2+/calmodulin-dependent protein kinase), and a serine/proline-rich domain in between the doublecortin and the protein kinase domains (which mediates multiple protein-protein interactions). DCAMKL1 is a microtubule-associated kinase that can undergo autophosphorylation. DCAMKL1 has microtubule-polymerizing activity that is independent of its protein kinase activity. DCAMKL1 is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Calcium/calmodulin-dependent protein kinase type I-like CPG16; CLICK-I beta; double cortin and calcium/calmodulin-dependent protein kinase-like 1; doublecortin and calcium/calmodulin-dependent protein kinase-like 1; Doublecortin domain-containing protein 3A; Doublecortin-like and CAM kinase-like 1; Doublecortin-like kinase 1; KIAA0369; RP11-113P14.1; Serine/threonine-protein kinase DCLK1; unnamed protein product
Gene Aliases: 1700113D08Rik; 2810480F11Rik; AI836758; Ania4; CL1; Click-I; CLICK1; Cpg16; DCAMKL1; DCDC3A; Dcl; DCLK; DCLK1; KIAA0369; mKIAA0369
UniProt ID: (Human) O15075, (Mouse) Q9JLM8, (Rat) O08875
Entrez Gene ID: (Human) 9201, (Pig) 100623824, (Rabbit) 100339938, (Mouse) 13175, (Rat) 83825
protein phosphorylation
nervous system development
central nervous system development
response to virus
endosomal transport
cell differentiation
protein localization to nucleus
intracellular signal transduction
axon extension
neuron migration
multicellular organism development
axonogenesis
brain development
phosphorylation
central nervous system projection neuron axonogenesis
forebrain development
dendrite morphogenesis
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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