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Proteintech
NDUFS1 Monoclonal Antibody (3H5E8)
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Product Details
68253-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Pig,
Rabbit,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
3H5E8
Immunogen
Recombinant protein
Conjugate
Form
Liquid
Purification
Protein G
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: MLRIPVRKAL VGLSKSPKGC VRTTATAASN LIEVFVDGQS VMVEPGTTVL QACEKVGMQI PRFCYHERLS VAGNCRMCLV EIEKAPKVVA ACAMPVMKGW NILTNSEKSK KAREGVMEFL LANHPLDCPI CDQGGECDLQ DQSMMFGNDR SRFLEGKRAV EDKNIGPLVK TIMTRCIQCT RCIRFASEIA GVDDLGTTGR GNDMQVGTYI EKMFMSELSG NIIDICPVGA LTSKPYAFTA QPWETRKTES IDVMDAVGSN IVVSTRTGEV MRILPRMHED INEEWISDKT RFAYDGLKRQ RLTEP
Target Information
The protein encoded by this gene belongs to the complex I 75 kDa subunit family. Mammalian complex I is composed of 45 different subunits. It locates at the mitochondrial inner membrane. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. This protein is the largest subunit of complex I and it is a component of the iron-sulfur fragment of the enzyme. It may form part of the active site crevice where NADH is oxidized. Mutations in this gene are associated with complex I deficiency. Several transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CI-75kD; complex I 75kDa subunit; complex I, mitochondrial respiratory chain, 75-kD subunit; Complex I-75kD; MGC26839; mitochondrial NADH-ubiquinone oxidoreductase 75 kDa subunit; NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa; NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase); NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial; NDUFS-1; OTTHUMP00000206345; unnamed protein product
Gene Aliases: 5830412M15Rik; 9930026A05Rik; CI-75k; CI-75Kd; MC1DN5; NDUFS1; PRO1304
UniProt ID: (Human) P28331, (Rat) Q66HF1, (Mouse) Q91VD9
Entrez Gene ID: (Human) 4719, (Pig) 100516402, (Rabbit) 100341941, (Rat) 301458, (Mouse) 227197
protein binding
NADH dehydrogenase (ubiquinone) activity
electron carrier activity
oxidoreductase activity
oxidoreductase activity, acting on NAD(P)H
metal ion binding
iron-sulfur cluster binding
2 iron, 2 sulfur cluster binding
4 iron, 4 sulfur cluster binding
molecular_function
NADH dehydrogenase activity
reductase
mitochondrial electron transport, NADH to ubiquinone
aerobic respiration
mitochondrial respiratory chain complex I assembly
ATP synthesis coupled electron transport
mitochondrial ATP synthesis coupled proton transport
cellular respiration
hydrogen ion transmembrane transport
biological_process
apoptotic mitochondrial changes
ATP metabolic process
regulation of mitochondrial membrane potential
reactive oxygen species metabolic process
transport
oxidation-reduction process
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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