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Invitrogen

RAGE Recombinant Rabbit Monoclonal Antibody (17H19L10)

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RAGE Recombinant Rabbit Monoclonal Antibody (17H19L10)

Product Details

701316

Applications
Tested Dilution
Publications

Western Blot (WB)

2-3 µg/mL
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Expression System

Expi293

Class

Recombinant Monoclonal

Type

Antibody

Clone

17H19L10

Immunogen

Recombinant protein corresponding to amino acids 23-342 of human sRAGE
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Protein A

Storage buffer

PBS

Contains

0.09% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2532469

Product Specific Information

This antibody is predicted to react with chimpanzee, equine, non-human primate and porcine based on sequence homology.

Intact IgG appears on a non-reducing gel as ~150 kDa band and upon reduction generating a ~25 kDa light chain band and a ~50 kDa heavy chain.

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

Target Information

The Receptor for Advanced Glycation End-products (RAGE) is a gene located on human chromosome 6p21.3, encoding a transmembrane receptor belonging to the immunoglobulin superfamily. RAGE is expressed in various tissues, with significant levels in the lungs, and plays a crucial role in cellular signaling and inflammation. As a receptor, RAGE binds multiple ligands, including advanced glycation end-products (AGEs), amyloid-beta peptide, high mobility group box 1 (HMGB1), and S100/calgranulin proteins, facilitating diverse pathological processes like inflammation, cancer progression, and neurodegeneration. The interaction between RAGE and its ligands triggers intracellular signaling pathways such as NF-kB activation, leading to inflammatory responses and oxidative stress. In the context of chronic diseases like diabetes, Alzheimer's, and cardiovascular diseases, RAGE is a critical mediator, linking metabolic disturbance to cellular dysfunction. Therapeutic targeting of RAGE signaling is under investigation, aiming to mitigate its contribution to inflammatory and degenerative diseases.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: advanced glycosylation end product receptor; Advanced glycosylation end product-specific receptor; RAGE-4 ORF3; RAGEdelex2-6; RAGEdelex3; RAGEdelex3-10; RAGEdelex3-7; RAGEdelex8&int9; RAGEint4; RAGEint4&9; RAGEint9&delex11; RAGEv1; RAGEv8; receptor for advanced glycation end-products; Receptor for advanced glycosylation end products; soluble receptor; sRAGE; unnamed protein product

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Gene Aliases: AGER; RAGE; SCARJ1; sRAGE

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UniProt ID: (Human) Q15109

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Entrez Gene ID: (Human) 177

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Function(s)
beta-amyloid binding DNA binding RNA binding transmembrane signaling receptor activity scavenger receptor activity laminin receptor activity protein binding signaling receptor activity histone binding identical protein binding S100 protein binding macromolecular complex binding advanced glycation end-product receptor activity binding, bridging
Process(es)
response to hypoxia microglial cell activation positive regulation of cytokine production regulation of T cell mediated cytotoxicity DNA replication DNA repair phagocytosis inflammatory response cellular response to DNA damage stimulus cell adhesion cell surface receptor signaling pathway learning or memory positive regulation of cell proliferation response to wounding negative regulation of biosynthetic process glucose mediated signaling pathway astrocyte development regulation of cell adhesion positive regulation of cell migration neuron projection development negative regulation of interleukin-10 production positive regulation of chemokine production positive regulation of interleukin-1 beta production positive regulation of interleukin-12 production positive regulation of interleukin-6 production positive regulation of tumor necrosis factor production positive regulation of heterotypic cell-cell adhesion positive regulation of activated T cell proliferation transcytosis positive regulation of cell differentiation positive regulation of JNK cascade astrocyte activation regulation of synaptic plasticity regulation of inflammatory response induction of positive chemotaxis positive regulation of DNA metabolic process positive regulation of NF-kappaB transcription factor activity negative regulation of multicellular organismal process positive regulation of ERK1 and ERK2 cascade cellular response to glucose stimulus positive regulation of monocyte chemotactic protein-1 production protein localization to membrane regulation of spontaneous synaptic transmission transport across blood-brain barrier regulation of long-term synaptic potentiation negative regulation of long-term synaptic potentiation negative regulation of long term synaptic depression regulation of p38MAPK cascade positive regulation of p38MAPK cascade regulation of NIK/NF-kappaB signaling positive regulation of NIK/NF-kappaB signaling positive regulation of amyloid precursor protein catabolic process negative regulation of blood circulation positive regulation of endothelin production negative regulation of connective tissue replacement involved in inflammatory response wound healing response to amyloid-beta cellular response to beta-amyloid positive regulation of DNA-dependent DNA replication positive regulation of monocyte extravasation regulation of CD4-positive, alpha-beta T cell activation positive regulation of double-strand break repair positive regulation of dendritic cell differentiation
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