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Invitrogen
FASN Recombinant Rabbit Monoclonal Antibody (10H14L16)
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FIGURE: 1 / 7
FASN Antibody (702060) in ICC/IF
Immunofluorescence analysis of FASN was performed using 70% confluent log phase Hep G2 cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes, and blocked with 2% BSA for 45 minutes at room temperature. The cells were labeled with FASN Recombinant Rabbit Monoclonal Antibody (10H14L16) (Product # 702060) at 2 µg/mL in 0.1% BSA, incubated at 4 degree celsius overnight and then labeled with Donkey anti-Rabbit IgG (H+L) Highly Cross-Adsorbed Secondary Antibody, Alexa Fluor Plus... View More
Product Details
702060
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Expression System
Expi293
Class
Recombinant Monoclonal
Type
Antibody
Clone
10H14L16
Immunogen
Protein corresponding to Human FASN (aa 2200-2470)
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
Product Specific Information
This antibody is predicted to react with Monkey and galago.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
Target Information
Fatty acid synthase is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 3-hydroxyacyl-[acyl-carrier-protein] dehydratase; 3-oxoacyl-[acyl-carrier-protein] reductase; 3-oxoacyl-[acyl-carrier-protein] synthase; [Acyl-carrier-protein] S-acetyltransferase; [Acyl-carrier-protein] S-malonyltransferase; Acyl-[acyl-carrier-protein] hydrolase; encodes region of fatty acid synthase activity; FAS; multifunctional protein; Enoyl-[acyl-carrier-protein] reductase; FAS; Fatty acid synthase; MGC14367; MGC15706; short chain dehydrogenase/reductase family 27X, member 1; Type I Fatty Acid Synthase
Gene Aliases: A630082H08Rik; FAS; FASN; OA-519; SDR27X1
UniProt ID: (Human) P49327, (Mouse) P19096
Entrez Gene ID: (Human) 2194, (Mouse) 14104
RNA binding
catalytic activity
fatty acid synthase activity
[acyl-carrier-protein] S-acetyltransferase activity
[acyl-carrier-protein] S-malonyltransferase activity
3-oxoacyl-[acyl-carrier-protein] synthase activity
3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
protein binding
acyl-[acyl-carrier-protein] hydrolase activity
oxidoreductase activity
transferase activity
transferase activity, transferring acyl groups
hydrolase activity
lyase activity
3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
phosphopantetheine binding
identical protein binding
cadherin binding
enoyl-[acyl-carrier-protein] reductase (NADPH) activity
3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity
enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity
oleoyl-[acyl-carrier-protein] hydrolase activity
drug binding
zinc ion binding
myristoyl-[acyl-carrier-protein] hydrolase activity
palmitoyl-[acyl-carrier-protein] hydrolase activity
hydrolase activity, acting on ester bonds
protein homodimerization activity
poly(A) RNA binding
enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
NADPH binding
osteoblast differentiation
epithelial cell development
acetyl-CoA metabolic process
lipid metabolic process
fatty acid metabolic process
fatty acid biosynthetic process
inflammatory response
response to nutrient
lipid biosynthetic process
ether lipid biosynthetic process
tissue development
neutrophil differentiation
monocyte differentiation
mammary gland development
response to nutrient levels
modulation by host of viral process
fatty-acyl-CoA biosynthetic process
response to caloric restriction
cellular response to interleukin-4
establishment of endothelial intestinal barrier
metabolic process
biosynthetic process
oxidation-reduction process
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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