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Invitrogen

Activin A Recombinant Rabbit Monoclonal Antibody (21H15L7)

View all (25) Activin A antibodies

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Activin A Recombinant Rabbit Monoclonal Antibody (21H15L7)

Product Details

702177

Applications
Tested Dilution
Publications

Immunocytochemistry (ICC/IF)

2 µg/mL
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Expression System

Expi293

Class

Recombinant Monoclonal

Type

Antibody

Clone

21H15L7

Immunogen

Peptides corresponding to Human INHBA (aa 262-279, 407-423)
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

PBS, pH 7.2

Contains

0.09% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2633063

Product Specific Information

This antibody is predicted to react with Monkey, Bovine, Sheep and Goat

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

Target Information

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Activin A mutations are associated with fibrodysplasia ossificans progressive.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Activin beta-A chain; beta-A inhibin; EDF; erythroid differentiation factor; Erythroid differentiation protein; erythroid differentiation protein precursor; follicle-stimulating hormone-releasing protein; FSH-releasing protein; Inhibin beta A chain; inhibin beta A subunit; inhibin, beta A (activin A, activin AB alpha polypeptide); Inhibin, beta-1; unnamed protein product

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Gene Aliases: EDF; FRP; INHBA

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UniProt ID: (Human) P08476

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Entrez Gene ID: (Human) 3624

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Function(s)
receptor binding cytokine activity hormone activity protein binding growth factor activity peptide hormone binding identical protein binding macromolecular complex binding type II activin receptor binding
Process(es)
ovarian follicle development mesoderm formation hair follicle development hematopoietic progenitor cell differentiation regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter lipid metabolic process steroid biosynthetic process autophagy defense response cell surface receptor signaling pathway transmembrane receptor protein serine/threonine kinase signaling pathway cell-cell signaling nervous system development steroid metabolic process androgen metabolic process negative regulation of cell proliferation male gonad development response to wounding gene expression positive regulation of gene expression cytokine-mediated signaling pathway striatal medium spiny neuron differentiation cell differentiation erythrocyte differentiation negative regulation of cell growth negative regulation of interferon-gamma production activin receptor signaling pathway positive regulation of collagen biosynthetic process endodermal cell differentiation negative regulation of phosphorylation odontogenesis hemoglobin biosynthetic process progesterone secretion negative regulation of B cell differentiation positive regulation of erythrocyte differentiation negative regulation of macrophage differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of transcription from RNA polymerase III promoter regulation of follicle-stimulating hormone secretion positive regulation of follicle-stimulating hormone secretion negative regulation of follicle-stimulating hormone secretion mesodermal cell differentiation cell development animal organ development system development positive regulation of protein metabolic process Sertoli cell differentiation palate development positive regulation of ovulation positive regulation of SMAD protein import into nucleus SMAD protein signal transduction cardiac fibroblast cell development eyelid development in camera-type eye testosterone biosynthetic process positive regulation of ERK1 and ERK2 cascade cellular response to follicle-stimulating hormone stimulus cellular response to cholesterol cellular response to hypoxia cellular response to oxygen-glucose deprivation GABAergic neuron differentiation extrinsic apoptotic signaling pathway androst-4-ene-3,17-dione biosynthetic process response to aldosterone cellular response to angiotensin negative regulation of G1/S transition of mitotic cell cycle positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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