Search
Invitrogen
FXR1 Recombinant Rabbit Monoclonal Antibody (6H25L10)
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
FIGURE: 1 / 7
FXR1 Antibody (702410) in ICC/IF
For immunofluorescence analysis, SH-SY5Y cells were fixed and permeabilized for detection of endogenous FXR1 using Anti-FXR1 Recombinant Rabbit Monoclonal Antibody (Product # 702410, 5µg/mL) and labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, Alexa Fluor® 488 conjugate (Product # A27034, 1:2000). Nuclei (blue) is stained using SlowFade® Gold Antifade Mountant with DAPI (Product # S36938) and cytoskeletal F-actin (red) staining using Rhodamine Phalloidin (Product # R415, 1:300).Panel a-d) shows representativ... View More
Product Details
702410
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Expression System
Expi293
Class
Recombinant Monoclonal
Type
Antibody
Clone
6H25L10
Immunogen
Protein corresponding to human FXR1 (aa400-aa600)
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
Product Specific Information
This antibody is predicted to react with Monkey, Bovine, Sheep
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
Target Information
FXR1 is an RNA binding protein that interacts with the functionally-similar proteins FMR1 and FXR2. It may regulate intracellular transport and local transltion of certain mRNAs. These proteins shuttle between the nucleus and cytoplasm and associate with polyribosomes, predominantly with the 60S ribosomal subunit. FXR1 is required for embryonic and postnatal development of muscle tissue. Three transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: FMR1 autosomal homolog 1; FMR1 autosomal protein-like protein 1; fragile X mental retardation gene, autosomal homolog; fragile X mental retardation syndrome-related protein 1; fragile X mental retardation-related protein 1; fragile-X-related protein 1; FXR1P; hFXR1p; mFxr1p; RNA-binding protein FXR1; unnamed protein product
Gene Aliases: 1110050J02Rik; 9530073J07Rik; AI851072; CMYO9A; CMYO9B; CMYP9A; CMYP9B; FXR1; Fxr1h; FXR1P; MYOPMIL; MYORIBF
UniProt ID: (Human) P51114, (Mouse) Q61584
Entrez Gene ID: (Human) 8087, (Mouse) 14359
nucleic acid binding
RNA binding
mRNA binding
mRNA 3'-UTR binding
protein binding
RNA strand annealing activity
mRNA 3'-UTR AU-rich region binding
protein homodimerization activity
ribonucleoprotein complex binding
translation regulator activity
protein heterodimerization activity
molecular condensate scaffold activity
G-quadruplex RNA binding
poly(A) RNA binding
translation factor
cytoplasmic translational initiation
regulation of translation
apoptotic process
spermatogenesis
spermatid development
muscle organ development
posttranscriptional regulation of gene expression
negative regulation of translation
dentate gyrus development
cell differentiation
negative regulation of tumor necrosis factor production
positive regulation of Rho protein signal transduction
regulation of mRNA stability
regulation of circadian sleep/wake cycle, sleep
positive regulation of translation
positive regulation of long-term neuronal synaptic plasticity
animal organ development
negative regulation of inflammatory response
regulation of neurogenesis
mRNA transport
nuclear pore complex assembly
nuclear pore localization
regulation of synaptic transmission, glutamatergic
skeletal muscle organ development
muscle structure development
mRNA destabilization
regulation of translation at presynapse, modulating synaptic transmission
membraneless organelle assembly
negative regulation of long-term synaptic potentiation
negative regulation of mRNA catabolic process
positive regulation of gene silencing by miRNA
multicellular organism development
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support