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Invitrogen
Catalase Recombinant Rabbit Monoclonal Antibody (10H47L17)
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FIGURE: 1 / 2
Catalase Antibody (702955) in ICC/IF
For immunofluorescence analysis, HepG2 cells were fixed and permeabilized for detection of endogenous Catalase using Anti- Catalase Recombinant Rabbit Monoclonal Antibody (Product # 702955, 5 µg/mL) and labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, Alexa Fluor® 488 conjugate (Product # A27034, 1:2000). Panel a) shows representative cells that were stained for detection and localization of Catalase protein (green), Panel b) is stained for nuclei (blue) using SlowFade® Gold Antifade Mountant with DAPI (Prod... View More
Product Details
702955
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
Expi293
Class
Recombinant Monoclonal
Type
Antibody
Clone
10H47L17
Immunogen
Protein corresponding to human Catalase [aa1-aa527]
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
Product Specific Information
This antibody is predicted to react with Monkey, Bovine, Pig, Sheep.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
Target Information
Catalase is a homotetrameric heme-containing enzyme present within the matrix of all peroxisomes. It carries out a dismutation reaction in which hydrogen peroxide is converted to water and oxygen. Human catalase has the last four amino acids (-KANL) at the extreme C-terminus for peroxisome targeting. The monomer of human catalase is 61.3 kDa in molecular size. Catalase has been implicated as an important factor in inflammation, mutagenesis, prevention of apoptosis, and stimulation of a wide spectrum of tumors. Loss of catalase leads to the human genetic disease, acatalasemia, or Takahara's disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CAT; Catalase; CTA1; epididymis secretory sperm binding protein; HGNC:1516; MGC138422; MGC138424; unnamed protein product
Gene Aliases: CAT
UniProt ID: (Human) P04040
Entrez Gene ID: (Human) 847
response to reactive oxygen species
osteoblast differentiation
ureteric bud development
response to hypoxia
kidney development
triglyceride metabolic process
response to oxidative stress
cholesterol metabolic process
aerobic respiration
response to xenobiotic stimulus
response to UV
response to toxic substance
response to light intensity
UV protection
response to ozone
response to lead ion
response to activity
response to inactivity
hemoglobin metabolic process
response to estradiol
response to insulin
response to vitamin A
response to vitamin E
response to L-ascorbic acid
response to hydrogen peroxide
hydrogen peroxide catabolic process
negative regulation of apoptotic process
response to ethanol
response to cadmium ion
positive regulation of cell division
positive regulation of protein kinase B signaling
response to hyperoxia
cellular detoxification of hydrogen peroxide
response to fatty acid
cellular response to growth factor stimulus
response to amitrole
response to phenylpropanoid
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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