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Invitrogen
TYRO3 Recombinant Rabbit Monoclonal Antibody (14H68L59)
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FIGURE: 1 / 3
TYRO3 Antibody (703554) in WB
Western blot analysis was performed on membrane enriched extracts (30 µg lysate) of HCT 116 (Lane 1), SK-OV-3 (Lane 2), HeLa (Lane 3), COS-7 (Lane 4), Hep G2 (Lane 5) and tissue extracts of Mouse Brain (Lane 6) and Rat Brain (Lane 7). The blot was probed with Anti-TYRO3 Recombinant Rabbit Monoclonal Antibody (Product # 703554, 1:1000 dilution) and detected by chemiluminescence using Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, HRP conjugate (Product # A27036, 1:5000 dilution). A ~130 kDa band corresponding to TYRO3 w... View More
Product Details
703554
Product Specifications
Species Reactivity
Human,
Mouse,
Non-human primate,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
Expi293
Class
Recombinant Monoclonal
Type
Antibody
Clone
14H68L59
Immunogen
Protein corresponding to human TYRO3 [aa790-aa890]
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
Product Specific Information
This antibody is predicted to react with Monkey, Pig, Bovine, Cat.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
Target Information
TYRO3 (tyrosine-protein kinase receptor TYRO3) is a receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. It regulates many physiological processes including cell survival, migration, and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by a ligand, TYRO3 plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation, signal transduction, cell adhesion. and cytoskeleton reorganization.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Bruton agammaglobulinemia tyrosine kinase; Etk2/tyro3; FLJ16467; soluble tyro 3; soluble tyro3; styro 3; styro3; TK19-2; tyro 3; TYRO3; TYRO3 protein tyrosine kinase 3; Tyrosine-protein kinase BYK; Tyrosine-protein kinase DTK; Tyrosine-protein kinase receptor TYRO3; Tyrosine-protein kinase RSE; Tyrosine-protein kinase SKY; Tyrosine-protein kinase TIF; unnamed protein product
Gene Aliases: AI323366; Brt; BYK; DTK; Etk-2; etk2/tyro3; Rek; RSE; SKY; TIF; TK19-2; TYRO3
UniProt ID: (Human) Q06418, (Mouse) P55144, (Rat) P55146
Entrez Gene ID: (Human) 7301, (Mouse) 22174, (Rat) 25232
nucleotide binding
virus receptor activity
protein kinase activity
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
protein binding
ATP binding
kinase activity
transferase activity
phosphatidylinositol 3-kinase binding
transferase activity, transferring phosphorus-containing groups
protein heterodimerization activity
transmembrane signal receptor
neuron migration
natural killer cell differentiation
phagocytosis
cell adhesion
signal transduction
transmembrane receptor protein tyrosine kinase signaling pathway
neuropeptide signaling pathway
spermatogenesis
nervous system development
cell migration
forebrain cell migration
platelet activation
secretion by cell
negative regulation of toll-like receptor signaling pathway
substrate adhesion-dependent cell spreading
ovulation cycle
apoptotic cell clearance
protein kinase B signaling
negative regulation of neuron apoptotic process
negative regulation of innate immune response
lymphocyte activation
viral entry into host cell
negative regulation of inflammatory response
negative regulation of lymphocyte activation
neuron apoptotic process
establishment of localization in cell
positive regulation of protein kinase B signaling
vagina development
neuron cellular homeostasis
platelet aggregation
positive regulation of viral life cycle
protein phosphorylation
phosphorylation
peptidyl-tyrosine phosphorylation
protein autophosphorylation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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