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Invitrogen

Alpha-2a Adrenergic Receptor Recombinant Rabbit Monoclonal Antibody (3H29L10)

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Alpha-2a Adrenergic Receptor Recombinant Rabbit Monoclonal Antibody (3H29L10)

Product Details

703636

Applications
Tested Dilution
Publications

Immunocytochemistry (ICC/IF)

1:100
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Expression System

Expi293

Class

Recombinant Monoclonal

Type

Antibody

Clone

3H29L10

Immunogen

Peptides corresponding to human Alpha-2a Adrenergic Receptor [1) aa225-aa238 2) aa180-aa194]
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

PBS, pH 7.4

Contains

0.09% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2762396

Product Specific Information

This antibody is predicted to react with Monkey, Cat, Pig, Mouse.

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

Target Information

Alpha-2-adrenergic receptors (ADRA2A) are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. ADRA2A mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G protein. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: adrenergic, alpha-2A-, receptor; Alpha-2 adrenergic receptor subtype C10; alpha-2-adrenergic receptor, platelet type; Alpha-2A adrenergic receptor; Alpha-2A adrenoceptor; Alpha-2A adrenoreceptor; alpha-2AAR subtype C10; OTTHUMP00000058849

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Gene Aliases: ADRA2; ADRA2A; ADRA2R; ADRAR; ALPHA2AAR; FPLD8; ZNF32

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UniProt ID: (Human) P08913

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Entrez Gene ID: (Human) 150

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Function(s)
G-protein coupled receptor activity adrenergic receptor activity alpha2-adrenergic receptor activity guanyl-nucleotide exchange factor activity protein binding protein kinase binding alpha-1B adrenergic receptor binding alpha-2C adrenergic receptor binding thioesterase binding heterotrimeric G-protein binding protein homodimerization activity protein heterodimerization activity epinephrine binding norepinephrine binding
Process(es)
positive regulation of cytokine production DNA replication regulation of smooth muscle contraction signal transduction epidermal growth factor receptor signaling pathway G-protein coupled receptor signaling pathway adenylate cyclase-activating G-protein coupled receptor signaling pathway adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Ras protein signal transduction Rho protein signal transduction female pregnancy positive regulation of cell proliferation negative regulation of norepinephrine secretion regulation of vasoconstriction actin cytoskeleton organization platelet activation positive regulation of cell migration negative regulation of epinephrine secretion cellular response to hormone stimulus vasodilation glucose homeostasis fear response positive regulation of potassium ion transport response to morphine positive regulation of MAPK cascade positive regulation of epidermal growth factor receptor signaling pathway negative regulation of calcium ion-dependent exocytosis negative regulation of insulin secretion intestinal absorption thermoception negative regulation of lipid catabolic process positive regulation of membrane protein ectodomain proteolysis positive regulation of protein kinase B signaling negative regulation of calcium ion transport negative regulation of insulin secretion involved in cellular response to glucose stimulus negative regulation of uterine smooth muscle contraction adrenergic receptor signaling pathway adenylate cyclase-activating adrenergic receptor signaling pathway adenylate cyclase-inhibiting adrenergic receptor signaling pathway phospholipase C-activating adrenergic receptor signaling pathway positive regulation of wound healing response to alcohol presynaptic modulation of chemical synaptic transmission
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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